ID   HPE_HAEIN               Reviewed;         160 AA.
AC   P43961;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Surface-adhesin protein E;
DE   Flags: Precursor;
GN   Name=pe; OrderedLocusNames=HI_0178;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Acts as a multifunctional adhesin involved in direct
CC       interactions with host epithelial cells and host proteins.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Lipid-anchor
CC       {ECO:0000255|PROSITE-ProRule:PRU00303}. Cell surface {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L42023; AAC21855.1; -; Genomic_DNA.
DR   PIR; F64003; F64003.
DR   RefSeq; NP_438346.1; NC_000907.1.
DR   RefSeq; WP_005694109.1; NC_000907.1.
DR   PDB; 3ZH7; X-ray; 2.10 A; A=28-153.
DR   PDBsum; 3ZH7; -.
DR   AlphaFoldDB; P43961; -.
DR   SMR; P43961; -.
DR   STRING; 71421.HI_0178; -.
DR   EnsemblBacteria; AAC21855; AAC21855; HI_0178.
DR   KEGG; hin:HI_0178; -.
DR   PATRIC; fig|71421.8.peg.182; -.
DR   eggNOG; ENOG5031K7A; Bacteria.
DR   HOGENOM; CLU_144598_0_0_6; -.
DR   OMA; DSIWVDN; -.
DR   BioCyc; HINF71421:G1GJ1-188-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.40.128.710; -; 1.
DR   InterPro; IPR043088; Adhesin_E.
DR   InterPro; IPR031939; Adhesin_E-like.
DR   InterPro; IPR016595; Adhesin_E_Pasteurellaceae.
DR   Pfam; PF16747; Adhesin_E; 1.
DR   PIRSF; PIRSF012320; Prplsmic_HI0178_prd; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell outer membrane; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome; Signal; Virulence.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           16..160
FT                   /note="Surface-adhesin protein E"
FT                   /id="PRO_0000013953"
FT   LIPID           16
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           16
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   STRAND          40..43
FT                   /evidence="ECO:0007829|PDB:3ZH7"
FT   STRAND          46..58
FT                   /evidence="ECO:0007829|PDB:3ZH7"
FT   STRAND          65..78
FT                   /evidence="ECO:0007829|PDB:3ZH7"
FT   STRAND          81..83
FT                   /evidence="ECO:0007829|PDB:3ZH7"
FT   STRAND          88..98
FT                   /evidence="ECO:0007829|PDB:3ZH7"
FT   TURN            99..102
FT                   /evidence="ECO:0007829|PDB:3ZH7"
FT   STRAND          103..115
FT                   /evidence="ECO:0007829|PDB:3ZH7"
FT   STRAND          119..122
FT                   /evidence="ECO:0007829|PDB:3ZH7"
FT   STRAND          130..133
FT                   /evidence="ECO:0007829|PDB:3ZH7"
FT   STRAND          136..138
FT                   /evidence="ECO:0007829|PDB:3ZH7"
FT   HELIX           139..151
FT                   /evidence="ECO:0007829|PDB:3ZH7"
SQ   SEQUENCE   160 AA;  18360 MW;  D0F685EBCC9085DF CRC64;
     MKKIILTLSL GLLTACSAQI QKAEQNDVKL APPTDVRSGY IRLVKNVNYY IDSESIWVDN
     QEPQIVHFDA VVNLDRGLYV YPEPKRYARS VRQYKILNCA NYHLTQIRTD FYDEFWGQGL
     RAAPKKQKKH TLSLTPDTTL YNAAQIICAN YGKAFSVDKK