ID   HPF1L_HUMAN             Reviewed;         347 AA.
AC   A8MVJ9;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Putative histone PARylation factor 1-like {ECO:0000305};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
CC   -!- SIMILARITY: Belongs to the HPF1 family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AL592293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A8MVJ9; -.
DR   SMR; A8MVJ9; -.
DR   IntAct; A8MVJ9; 2.
DR   MINT; A8MVJ9; -.
DR   BioMuta; -; -.
DR   jPOST; A8MVJ9; -.
DR   MassIVE; A8MVJ9; -.
DR   MaxQB; A8MVJ9; -.
DR   PeptideAtlas; A8MVJ9; -.
DR   PRIDE; A8MVJ9; -.
DR   neXtProt; NX_A8MVJ9; -.
DR   PhylomeDB; A8MVJ9; -.
DR   PathwayCommons; A8MVJ9; -.
DR   Pharos; A8MVJ9; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; A8MVJ9; protein.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0072572; F:poly-ADP-D-ribose binding; IBA:GO_Central.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IBA:GO_Central.
DR   GO; GO:0018312; P:peptidyl-serine ADP-ribosylation; IBA:GO_Central.
DR   GO; GO:0010835; P:regulation of protein ADP-ribosylation; IBA:GO_Central.
DR   InterPro; IPR019361; HPF1.
DR   PANTHER; PTHR13386; PTHR13386; 1.
DR   Pfam; PF10228; DUF2228; 1.
PE   5: Uncertain;
KW   Acetylation; Reference proteome.
FT   CHAIN           1..347
FT                   /note="Putative histone PARylation factor 1-like"
FT                   /id="PRO_0000342626"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NWY4"
FT   MOD_RES         187
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NWY4"
FT   MOD_RES         234
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NWY4"
SQ   SEQUENCE   347 AA;  39722 MW;  70EED2F152C48094 CRC64;
     MVGGGWKRRP GAGAGPQCEK TVDVKKSKFC EADVSSDLRK EVENHYTLSL PEDFYHFWKF
     CEELDSEKPA DPLSASLGLQ LVDPYNILAG KHKMKKKSTV PNFNLHWRFY YDPPEFQTII
     IRDKLSATWG ISDRDSPDEL PVYVGINEAK KNCIIVPNGD NVFAAVKLYL MKKLKEVTDK
     KKTNLFKNVD EKLTETAREL GYSLEQRTMK MKQRDKKVVT KTFHGTGLVP PVDKNVVGYR
     ELPETDADLK RICKTIVEAA SDDERRKAFA PIQEMMTFVQ FANDECDYGM GLELGMDLFC
     YGSHYFHKVA GQLLPLAYNL LKRNLFAEIM KDHLANRRKE NIDQFAA