ID   HPF_CUPNH               Reviewed;         116 AA.
AC   P28613; Q0KEN5;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Ribosome hibernation promoting factor;
DE            Short=HPF;
DE   AltName: Full=Hibernation factor HPF;
GN   Name=hpf; OrderedLocusNames=H16_A0386;
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1417413; DOI=10.1007/bf00245213;
RA   Warrelmann J., Eitinger M., Schwartz E., Rermann D., Friedrich B.;
RT   "Nucleotide sequence of the rpoN (hno) gene region of Alcaligenes
RT   eutrophus: evidence for a conserved gene cluster.";
RL   Arch. Microbiol. 158:107-114(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- FUNCTION: During stationary phase, promotes and stabilizes dimerization
CC       of 70S ribosomes by the ribosome modulation factor (RMF), leading to
CC       the formation of inactive 100S ribosomes.
CC       {ECO:0000250|UniProtKB:P0AFX0}.
CC   -!- SUBUNIT: Associates exclusively with 100S ribosomes, which are dimers
CC       of 70S ribosomes. {ECO:0000250|UniProtKB:P0AFX0}.
CC   -!- SIMILARITY: Belongs to the HPF/YfiA ribosome-associated protein family.
CC       Short HPF subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA47288.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X66793; CAA47288.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AM260479; CAJ91536.1; -; Genomic_DNA.
DR   PIR; C48362; C48362.
DR   RefSeq; WP_010814386.1; NZ_CP039287.1.
DR   AlphaFoldDB; P28613; -.
DR   SMR; P28613; -.
DR   STRING; 381666.H16_A0386; -.
DR   EnsemblBacteria; CAJ91536; CAJ91536; H16_A0386.
DR   GeneID; 57642481; -.
DR   KEGG; reh:H16_A0386; -.
DR   eggNOG; COG1544; Bacteria.
DR   HOGENOM; CLU_071472_3_1_4; -.
DR   OMA; NLTGHHI; -.
DR   OrthoDB; 2088581at2; -.
DR   Proteomes; UP000008210; Chromosome 1.
DR   GO; GO:0044238; P:primary metabolic process; IEA:InterPro.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   CDD; cd00552; RaiA; 1.
DR   Gene3D; 3.30.160.100; -; 1.
DR   InterPro; IPR036567; RHF-like.
DR   InterPro; IPR003489; RHF/RaiA.
DR   Pfam; PF02482; Ribosomal_S30AE; 1.
DR   SUPFAM; SSF69754; SSF69754; 1.
DR   TIGRFAMs; TIGR00741; yfiA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Translation regulation.
FT   CHAIN           1..116
FT                   /note="Ribosome hibernation promoting factor"
FT                   /id="PRO_0000097424"
SQ   SEQUENCE   116 AA;  13645 MW;  E6AFD10BF1ADD571 CRC64;
     MNFKISGHHL DITPPLREYV ETKLERIVRH FDQVIGVSVL LSVDNHKEKD RRQYAEINLH
     LKGKDIFVEA HHEDLYAAID ALVDKLDRQV IRYKDRVQGH DREAVKYQMA AAQMQQ