HPF_ECO57
ID HPF_ECO57 Reviewed; 95 AA.
AC P0AFX2; P31221;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Ribosome hibernation promoting factor;
DE Short=HPF;
DE AltName: Full=Hibernation factor HPF;
GN Name=hpf; OrderedLocusNames=Z4566, ECs4082;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: During stationary phase, promotes and stabilizes dimerization
CC of 70S ribosomes by the ribosome modulation factor (RMF), leading to
CC the formation of inactive 100S ribosomes.
CC {ECO:0000250|UniProtKB:P0AFX0}.
CC -!- SUBUNIT: Associates exclusively with 100S ribosomes, which are dimers
CC of 70S ribosomes. {ECO:0000250|UniProtKB:P0AFX0}.
CC -!- INDUCTION: Induced during stationary growth phase. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HPF/YfiA ribosome-associated protein family.
CC Short HPF subfamily. {ECO:0000305}.
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DR EMBL; AE005174; AAG58337.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB37505.1; -; Genomic_DNA.
DR PIR; B91139; B91139.
DR PIR; E85984; E85984.
DR RefSeq; NP_312109.1; NC_002695.1.
DR RefSeq; WP_001176599.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; P0AFX2; -.
DR BMRB; P0AFX2; -.
DR SMR; P0AFX2; -.
DR STRING; 155864.EDL933_4431; -.
DR EnsemblBacteria; AAG58337; AAG58337; Z4566.
DR EnsemblBacteria; BAB37505; BAB37505; ECs_4082.
DR GeneID; 66672895; -.
DR GeneID; 916070; -.
DR KEGG; ece:Z4566; -.
DR KEGG; ecs:ECs_4082; -.
DR PATRIC; fig|386585.9.peg.4261; -.
DR eggNOG; COG1544; Bacteria.
DR HOGENOM; CLU_071472_3_1_6; -.
DR OMA; NLTGHHI; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0044238; P:primary metabolic process; IEA:InterPro.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd00552; RaiA; 1.
DR Gene3D; 3.30.160.100; -; 1.
DR InterPro; IPR036567; RHF-like.
DR InterPro; IPR003489; RHF/RaiA.
DR Pfam; PF02482; Ribosomal_S30AE; 1.
DR SUPFAM; SSF69754; SSF69754; 1.
DR TIGRFAMs; TIGR00741; yfiA; 1.
PE 3: Inferred from homology;
KW Reference proteome; Translation regulation.
FT CHAIN 1..95
FT /note="Ribosome hibernation promoting factor"
FT /id="PRO_0000097419"
SQ SEQUENCE 95 AA; 10750 MW; 5B8F737E6E3A91AE CRC64;
MQLNITGNNV EITEALREFV TAKFAKLEQY FDRINQVYVV LKVEKVTHTS DATLHVNGGE
IHASAEGQDM YAAIDGLIDK LARQLTKHKD KLKQH
