ID   HPF_ECOL6               Reviewed;          95 AA.
AC   P0AFX1; P31221;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Ribosome hibernation promoting factor;
DE            Short=HPF;
DE   AltName: Full=Hibernation factor HPF;
GN   Name=hpf; OrderedLocusNames=c3963;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: During stationary phase, promotes and stabilizes dimerization
CC       of 70S ribosomes by the ribosome modulation factor (RMF), leading to
CC       the formation of inactive 100S ribosomes.
CC       {ECO:0000250|UniProtKB:P0AFX0}.
CC   -!- SUBUNIT: Associates exclusively with 100S ribosomes, which are dimers
CC       of 70S ribosomes. {ECO:0000250|UniProtKB:P0AFX0}.
CC   -!- INDUCTION: Induced during stationary growth phase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HPF/YfiA ribosome-associated protein family.
CC       Short HPF subfamily. {ECO:0000305}.
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DR   EMBL; AE014075; AAN82403.1; -; Genomic_DNA.
DR   RefSeq; WP_001176599.1; NC_004431.1.
DR   AlphaFoldDB; P0AFX1; -.
DR   BMRB; P0AFX1; -.
DR   SMR; P0AFX1; -.
DR   STRING; 199310.c3963; -.
DR   EnsemblBacteria; AAN82403; AAN82403; c3963.
DR   GeneID; 66672895; -.
DR   KEGG; ecc:c3963; -.
DR   eggNOG; COG1544; Bacteria.
DR   HOGENOM; CLU_071472_3_1_6; -.
DR   OMA; NLTGHHI; -.
DR   BioCyc; ECOL199310:C3963-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0044238; P:primary metabolic process; IEA:InterPro.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   CDD; cd00552; RaiA; 1.
DR   Gene3D; 3.30.160.100; -; 1.
DR   InterPro; IPR036567; RHF-like.
DR   InterPro; IPR003489; RHF/RaiA.
DR   Pfam; PF02482; Ribosomal_S30AE; 1.
DR   SUPFAM; SSF69754; SSF69754; 1.
DR   TIGRFAMs; TIGR00741; yfiA; 1.
PE   3: Inferred from homology;
KW   Translation regulation.
FT   CHAIN           1..95
FT                   /note="Ribosome hibernation promoting factor"
FT                   /id="PRO_0000097418"
SQ   SEQUENCE   95 AA;  10750 MW;  5B8F737E6E3A91AE CRC64;
     MQLNITGNNV EITEALREFV TAKFAKLEQY FDRINQVYVV LKVEKVTHTS DATLHVNGGE
     IHASAEGQDM YAAIDGLIDK LARQLTKHKD KLKQH