ID   HPF_KLEOX               Reviewed;          95 AA.
AC   P17161; P11377;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Ribosome hibernation promoting factor;
DE            Short=HPF;
DE   AltName: Full=Hibernation factor HPF;
GN   Name=hpf;
OS   Klebsiella oxytoca.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=571;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M5a1;
RX   PubMed=2695747; DOI=10.1111/j.1365-2958.1989.tb00162.x;
RA   Merrick M.J., Coppard J.R.;
RT   "Mutations in genes downstream of the rpoN gene (encoding sigma 54) of
RT   Klebsiella pneumoniae affect expression from sigma 54-dependent
RT   promoters.";
RL   Mol. Microbiol. 3:1765-1775(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-75.
RX   PubMed=2999700; DOI=10.1093/nar/13.21.7607;
RA   Merrick M.J., Gibbins J.R.;
RT   "The nucleotide sequence of the nitrogen-regulation gene ntrA of Klebsiella
RT   pneumoniae and comparison with conserved features in bacterial RNA
RT   polymerase sigma factors.";
RL   Nucleic Acids Res. 13:7607-7620(1985).
CC   -!- FUNCTION: During stationary phase, promotes and stabilizes dimerization
CC       of 70S ribosomes by the ribosome modulation factor (RMF), leading to
CC       the formation of inactive 100S ribosomes.
CC       {ECO:0000250|UniProtKB:P0AFX0}.
CC   -!- SUBUNIT: Associates exclusively with 100S ribosomes, which are dimers
CC       of 70S ribosomes. {ECO:0000250|UniProtKB:P0AFX0}.
CC   -!- SIMILARITY: Belongs to the HPF/YfiA ribosome-associated protein family.
CC       Short HPF subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X16335; CAA34391.1; -; Genomic_DNA.
DR   EMBL; X03147; CAA26926.1; -; Genomic_DNA.
DR   PIR; S07660; S07660.
DR   RefSeq; WP_004106167.1; NZ_WVTN01000004.1.
DR   AlphaFoldDB; P17161; -.
DR   SMR; P17161; -.
DR   STRING; 571.MC52_05300; -.
DR   GeneID; 64335457; -.
DR   GeneID; 66587662; -.
DR   eggNOG; COG1544; Bacteria.
DR   OrthoDB; 2088581at2; -.
DR   GO; GO:0044238; P:primary metabolic process; IEA:InterPro.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   CDD; cd00552; RaiA; 1.
DR   Gene3D; 3.30.160.100; -; 1.
DR   InterPro; IPR036567; RHF-like.
DR   InterPro; IPR003489; RHF/RaiA.
DR   Pfam; PF02482; Ribosomal_S30AE; 1.
DR   SUPFAM; SSF69754; SSF69754; 1.
DR   TIGRFAMs; TIGR00741; yfiA; 1.
PE   3: Inferred from homology;
KW   Translation regulation.
FT   CHAIN           1..95
FT                   /note="Ribosome hibernation promoting factor"
FT                   /id="PRO_0000097421"
SQ   SEQUENCE   95 AA;  10759 MW;  1AD7789A96704169 CRC64;
     MQLNITGHNV EITPAMRDFV TAKFSKLEQF FDRINQVYIV LKVEKVTQIA DANLHVNGGE
     IHASAEGQDM YAAIDGLIDK LARQLTKHKD KLKQH