ID   HPF_SALTY               Reviewed;          95 AA.
AC   P26983;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Ribosome hibernation promoting factor;
DE            Short=HPF;
DE   AltName: Full=Hibernation factor HPF;
GN   Name=hpf; OrderedLocusNames=STM3321;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1918063; DOI=10.1016/s0021-9258(18)55025-0;
RA   Popham D.L., Keener J., Kustu S.;
RT   "Purification of the alternative sigma factor, sigma 54, from Salmonella
RT   typhimurium and characterization of sigma 54-holoenzyme.";
RL   J. Biol. Chem. 266:19510-19518(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: During stationary phase, promotes and stabilizes dimerization
CC       of 70S ribosomes by the ribosome modulation factor (RMF), leading to
CC       the formation of inactive 100S ribosomes.
CC       {ECO:0000250|UniProtKB:P0AFX0}.
CC   -!- SUBUNIT: Associates exclusively with 100S ribosomes, which are dimers
CC       of 70S ribosomes. {ECO:0000250|UniProtKB:P0AFX0}.
CC   -!- INDUCTION: Induced during stationary growth phase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HPF/YfiA ribosome-associated protein family.
CC       Short HPF subfamily. {ECO:0000305}.
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DR   EMBL; M68571; AAA27225.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL22190.1; -; Genomic_DNA.
DR   PIR; B41026; B41026.
DR   RefSeq; NP_462231.1; NC_003197.2.
DR   RefSeq; WP_001176589.1; NC_003197.2.
DR   AlphaFoldDB; P26983; -.
DR   SMR; P26983; -.
DR   STRING; 99287.STM3321; -.
DR   PaxDb; P26983; -.
DR   EnsemblBacteria; AAL22190; AAL22190; STM3321.
DR   GeneID; 1254844; -.
DR   GeneID; 66757660; -.
DR   KEGG; stm:STM3321; -.
DR   PATRIC; fig|99287.12.peg.3522; -.
DR   HOGENOM; CLU_071472_3_1_6; -.
DR   OMA; NLTGHHI; -.
DR   PhylomeDB; P26983; -.
DR   BioCyc; SENT99287:STM3321-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0043024; F:ribosomal small subunit binding; IBA:GO_Central.
DR   GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR   GO; GO:0045900; P:negative regulation of translational elongation; IBA:GO_Central.
DR   GO; GO:0044238; P:primary metabolic process; IEA:InterPro.
DR   CDD; cd00552; RaiA; 1.
DR   Gene3D; 3.30.160.100; -; 1.
DR   InterPro; IPR036567; RHF-like.
DR   InterPro; IPR003489; RHF/RaiA.
DR   Pfam; PF02482; Ribosomal_S30AE; 1.
DR   SUPFAM; SSF69754; SSF69754; 1.
DR   TIGRFAMs; TIGR00741; yfiA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Translation regulation.
FT   CHAIN           1..95
FT                   /note="Ribosome hibernation promoting factor"
FT                   /id="PRO_0000097426"
SQ   SEQUENCE   95 AA;  10857 MW;  D86D33A8C84D8B21 CRC64;
     MQLNITGHNV EITEALREFV TTKFAKLEQY FERINQVYVV LKVEKVTHIS DATLHVNGGE
     IHASAEGQDM YAAIDGLIDK LARQLTRHKD KLKQH