ID   HPF_SHIFL               Reviewed;          95 AA.
AC   P0AFX3; P31221;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Ribosome hibernation promoting factor;
DE            Short=HPF;
DE   AltName: Full=Hibernation factor HPF;
GN   Name=hpf; OrderedLocusNames=SF3243, S3461;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: During stationary phase, promotes and stabilizes dimerization
CC       of 70S ribosomes by the ribosome modulation factor (RMF), leading to
CC       the formation of inactive 100S ribosomes.
CC       {ECO:0000250|UniProtKB:P0AFX0}.
CC   -!- SUBUNIT: Associates exclusively with 100S ribosomes, which are dimers
CC       of 70S ribosomes. {ECO:0000250|UniProtKB:P0AFX0}.
CC   -!- INDUCTION: Induced during stationary growth phase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HPF/YfiA ribosome-associated protein family.
CC       Short HPF subfamily. {ECO:0000305}.
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DR   EMBL; AE005674; AAN44709.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18523.1; -; Genomic_DNA.
DR   RefSeq; NP_709002.1; NC_004337.2.
DR   RefSeq; WP_001176599.1; NZ_WPGW01000004.1.
DR   AlphaFoldDB; P0AFX3; -.
DR   BMRB; P0AFX3; -.
DR   SMR; P0AFX3; -.
DR   STRING; 198214.SF3243; -.
DR   EnsemblBacteria; AAN44709; AAN44709; SF3243.
DR   EnsemblBacteria; AAP18523; AAP18523; S3461.
DR   GeneID; 1027091; -.
DR   GeneID; 66672895; -.
DR   KEGG; sfl:SF3243; -.
DR   KEGG; sfx:S3461; -.
DR   PATRIC; fig|198214.7.peg.3844; -.
DR   HOGENOM; CLU_071472_3_1_6; -.
DR   OMA; NLTGHHI; -.
DR   OrthoDB; 2088581at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0044238; P:primary metabolic process; IEA:InterPro.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   CDD; cd00552; RaiA; 1.
DR   Gene3D; 3.30.160.100; -; 1.
DR   InterPro; IPR036567; RHF-like.
DR   InterPro; IPR003489; RHF/RaiA.
DR   Pfam; PF02482; Ribosomal_S30AE; 1.
DR   SUPFAM; SSF69754; SSF69754; 1.
DR   TIGRFAMs; TIGR00741; yfiA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Translation regulation.
FT   CHAIN           1..95
FT                   /note="Ribosome hibernation promoting factor"
FT                   /id="PRO_0000097420"
SQ   SEQUENCE   95 AA;  10750 MW;  5B8F737E6E3A91AE CRC64;
     MQLNITGNNV EITEALREFV TAKFAKLEQY FDRINQVYVV LKVEKVTHTS DATLHVNGGE
     IHASAEGQDM YAAIDGLIDK LARQLTKHKD KLKQH