HPF_STAEQ
ID HPF_STAEQ Reviewed; 189 AA.
AC Q5HQX7;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Ribosome hibernation promotion factor {ECO:0000255|HAMAP-Rule:MF_00839};
DE Short=HPF {ECO:0000255|HAMAP-Rule:MF_00839};
GN Name=hpf {ECO:0000255|HAMAP-Rule:MF_00839}; OrderedLocusNames=SERP0419;
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- FUNCTION: Required for dimerization of active 70S ribosomes into 100S
CC ribosomes in stationary phase; 100S ribosomes are translationally
CC inactive and sometimes present during exponential growth.
CC {ECO:0000255|HAMAP-Rule:MF_00839}.
CC -!- SUBUNIT: Interacts with 100S ribosomes. {ECO:0000255|HAMAP-
CC Rule:MF_00839}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00839}.
CC -!- SIMILARITY: Belongs to the HPF/YfiA ribosome-associated protein family.
CC Long HPF subfamily. {ECO:0000255|HAMAP-Rule:MF_00839}.
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DR EMBL; CP000029; AAW53825.1; -; Genomic_DNA.
DR RefSeq; WP_001829676.1; NC_002976.3.
DR AlphaFoldDB; Q5HQX7; -.
DR SMR; Q5HQX7; -.
DR STRING; 176279.SERP0419; -.
DR EnsemblBacteria; AAW53825; AAW53825; SERP0419.
DR GeneID; 50019318; -.
DR KEGG; ser:SERP0419; -.
DR eggNOG; COG1544; Bacteria.
DR HOGENOM; CLU_071472_0_3_9; -.
DR OMA; HGGYGVI; -.
DR OrthoDB; 1766263at2; -.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0044238; P:primary metabolic process; IEA:InterPro.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-UniRule.
DR CDD; cd00552; RaiA; 1.
DR Gene3D; 3.30.160.100; -; 1.
DR Gene3D; 3.30.505.50; -; 1.
DR HAMAP; MF_00839; HPF; 1.
DR InterPro; IPR034694; HPF_long/plastid.
DR InterPro; IPR036567; RHF-like.
DR InterPro; IPR003489; RHF/RaiA.
DR InterPro; IPR032528; Ribosom_S30AE_C.
DR InterPro; IPR038416; Ribosom_S30AE_C_sf.
DR Pfam; PF16321; Ribosom_S30AE_C; 1.
DR Pfam; PF02482; Ribosomal_S30AE; 1.
DR SUPFAM; SSF69754; SSF69754; 1.
DR TIGRFAMs; TIGR00741; yfiA; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Translation regulation.
FT CHAIN 1..189
FT /note="Ribosome hibernation promotion factor"
FT /id="PRO_0000291322"
SQ SEQUENCE 189 AA; 22064 MW; 5F2B3E964EDE494C CRC64;
MIRFEIHGDN LTITDAIRNY IEEKVGKLER YFNNVPNAVA HVRVKTYSNS TTKIEVTIPL
KDVTLRAEER HDDLYAGIDL ITNKLERQVR KYKTRVNRKH RDRGDQDIFV AEVQESTTNN
HADDIESEND IEIIRSKQFS LKPMDSEEAV LQMNLLGHDF FIFTDRETDG TSIVYRRKDG
KYGLIETTE
