ID   HPIP_BOVIN              Reviewed;         119 AA.
AC   Q2M2S6;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Host cell factor C1 regulator 1;
DE   AltName: Full=HCF-1 beta-propeller-interacting protein;
GN   Name=HCFC1R1; Synonyms=HPIP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates HCFC1 activity by modulating its subcellular
CC       localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1
CC       in the cytoplasm. HCFC1R1-mediated export may provide the pool of
CC       cytoplasmic HCFC1 required for import of virion-derived VP16 into the
CC       nucleus (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with HCFC1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent
CC       manner. {ECO:0000250}.
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DR   EMBL; BC111671; AAI11672.1; -; mRNA.
DR   RefSeq; NP_001039863.1; NM_001046398.2.
DR   AlphaFoldDB; Q2M2S6; -.
DR   STRING; 9913.ENSBTAP00000031487; -.
DR   PaxDb; Q2M2S6; -.
DR   Ensembl; ENSBTAT00000031534; ENSBTAP00000031487; ENSBTAG00000002367.
DR   GeneID; 535210; -.
DR   KEGG; bta:535210; -.
DR   CTD; 54985; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002367; -.
DR   VGNC; VGNC:29772; HCFC1R1.
DR   eggNOG; ENOG502SWHU; Eukaryota.
DR   GeneTree; ENSGT00390000015785; -.
DR   HOGENOM; CLU_166500_0_0_1; -.
DR   InParanoid; Q2M2S6; -.
DR   OMA; EDNMATH; -.
DR   OrthoDB; 1435515at2759; -.
DR   TreeFam; TF338381; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000002367; Expressed in laryngeal cartilage and 104 other tissues.
DR   ExpressionAtlas; Q2M2S6; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   InterPro; IPR029195; HCFC1R1.
DR   PANTHER; PTHR16246; PTHR16246; 2.
DR   Pfam; PF15226; HPIP; 2.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..119
FT                   /note="Host cell factor C1 regulator 1"
FT                   /id="PRO_0000338977"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          57..60
FT                   /note="Interaction with HCFC1"
FT                   /evidence="ECO:0000250"
FT   MOTIF           91..100
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   119 AA;  13216 MW;  89A6F17C58B2CE81 CRC64;
     MILQQPLERG PQGRAQRDPR AASGASGGLD AREPLRKQFL SEENMATHFS RLSLHNDHPY
     CSPPRAFPPA LPPLRSPCSE LLLWRYPGNL IPEALRLLRL GDTPTPHYPA SPAGDMMEL