HPIP_HUMAN
ID HPIP_HUMAN Reviewed; 138 AA.
AC Q9NWW0; D3DUA7; Q68EN7;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Host cell factor C1 regulator 1;
DE AltName: Full=HCF-1 beta-propeller-interacting protein;
GN Name=HCFC1R1; Synonyms=HPIP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR
RP LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF 76-ASP--TYR-79 AND
RP 117-LEU--LEU-119, AND INTERACTION WITH HCFC1.
RC TISSUE=Brain;
RX PubMed=12235138; DOI=10.1074/jbc.m205440200;
RA Mahajan S.S., Little M.M., Vazquez R., Wilson A.C.;
RT "Interaction of HCF-1 with a cellular nuclear export factor.";
RL J. Biol. Chem. 277:44292-44299(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP GLN-92.
RC TISSUE=Mammary gland, and PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Regulates HCFC1 activity by modulating its subcellular
CC localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1
CC in the cytoplasm. HCFC1R1-mediated export may provide the pool of
CC cytoplasmic HCFC1 required for import of virion-derived VP16 into the
CC nucleus. {ECO:0000269|PubMed:12235138}.
CC -!- SUBUNIT: Interacts with HCFC1. {ECO:0000269|PubMed:12235138}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12235138}. Nucleus
CC {ECO:0000269|PubMed:12235138}. Note=Shuttles between the nucleus and
CC cytoplasm in a CRM1-dependent manner.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NWW0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NWW0-2; Sequence=VSP_034082;
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:12235138}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY116892; AAM49798.1; -; mRNA.
DR EMBL; AK000575; BAA91265.1; -; mRNA.
DR EMBL; CR457245; CAG33526.1; -; mRNA.
DR EMBL; CH471112; EAW85425.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85426.1; -; Genomic_DNA.
DR EMBL; BC064026; AAH64026.1; -; mRNA.
DR EMBL; BC080178; AAH80178.1; -; mRNA.
DR CCDS; CCDS10490.1; -. [Q9NWW0-1]
DR CCDS; CCDS32375.1; -. [Q9NWW0-2]
DR RefSeq; NP_001002017.1; NM_001002017.2. [Q9NWW0-2]
DR RefSeq; NP_001002018.1; NM_001002018.2. [Q9NWW0-1]
DR RefSeq; NP_001275594.1; NM_001288665.1. [Q9NWW0-1]
DR RefSeq; NP_001275595.1; NM_001288666.1. [Q9NWW0-2]
DR RefSeq; NP_001275596.1; NM_001288667.1.
DR RefSeq; NP_001275597.1; NM_001288668.1.
DR RefSeq; NP_060355.1; NM_017885.3. [Q9NWW0-1]
DR AlphaFoldDB; Q9NWW0; -.
DR BioGRID; 120320; 3.
DR ELM; Q9NWW0; -.
DR IntAct; Q9NWW0; 3.
DR STRING; 9606.ENSP00000248089; -.
DR iPTMnet; Q9NWW0; -.
DR PhosphoSitePlus; Q9NWW0; -.
DR BioMuta; HCFC1R1; -.
DR MassIVE; Q9NWW0; -.
DR PaxDb; Q9NWW0; -.
DR PeptideAtlas; Q9NWW0; -.
DR PRIDE; Q9NWW0; -.
DR Antibodypedia; 42633; 106 antibodies from 15 providers.
DR DNASU; 54985; -.
DR Ensembl; ENST00000248089.8; ENSP00000248089.4; ENSG00000103145.11. [Q9NWW0-1]
DR Ensembl; ENST00000574151.5; ENSP00000459178.1; ENSG00000103145.11. [Q9NWW0-2]
DR Ensembl; ENST00000574980.5; ENSP00000460639.1; ENSG00000103145.11. [Q9NWW0-1]
DR GeneID; 54985; -.
DR KEGG; hsa:54985; -.
DR MANE-Select; ENST00000248089.8; ENSP00000248089.4; NM_017885.4; NP_060355.1.
DR UCSC; uc002csy.3; human. [Q9NWW0-1]
DR CTD; 54985; -.
DR DisGeNET; 54985; -.
DR GeneCards; HCFC1R1; -.
DR HGNC; HGNC:21198; HCFC1R1.
DR HPA; ENSG00000103145; Tissue enhanced (skeletal).
DR MIM; 618818; gene.
DR neXtProt; NX_Q9NWW0; -.
DR OpenTargets; ENSG00000103145; -.
DR PharmGKB; PA134951485; -.
DR VEuPathDB; HostDB:ENSG00000103145; -.
DR eggNOG; ENOG502SWHU; Eukaryota.
DR GeneTree; ENSGT00390000015785; -.
DR InParanoid; Q9NWW0; -.
DR OrthoDB; 1435515at2759; -.
DR PhylomeDB; Q9NWW0; -.
DR TreeFam; TF338381; -.
DR PathwayCommons; Q9NWW0; -.
DR SignaLink; Q9NWW0; -.
DR BioGRID-ORCS; 54985; 42 hits in 1079 CRISPR screens.
DR ChiTaRS; HCFC1R1; human.
DR GenomeRNAi; 54985; -.
DR Pharos; Q9NWW0; Tbio.
DR PRO; PR:Q9NWW0; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q9NWW0; protein.
DR Bgee; ENSG00000103145; Expressed in hindlimb stylopod muscle and 198 other tissues.
DR ExpressionAtlas; Q9NWW0; baseline and differential.
DR Genevisible; Q9NWW0; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR029195; HCFC1R1.
DR PANTHER; PTHR16246; PTHR16246; 2.
DR Pfam; PF15226; HPIP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..138
FT /note="Host cell factor C1 regulator 1"
FT /id="PRO_0000338978"
FT REGION 76..79
FT /note="Interaction with HCFC1"
FT /evidence="ECO:0000269|PubMed:12235138"
FT MOTIF 110..119
FT /note="Nuclear export signal"
FT VAR_SEQ 32..51
FT /note="SSPLRGAVPMSTKRRLEEEQ -> R (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12235138,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_034082"
FT VARIANT 92
FT /note="P -> Q (in dbSNP:rs10508)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_043849"
FT MUTAGEN 76..79
FT /note="DHPY->AAPA: Loss of interaction with HCFC1."
FT /evidence="ECO:0000269|PubMed:12235138"
FT MUTAGEN 117..119
FT /note="LRL->ARA: Reduces nuclear export."
FT /evidence="ECO:0000269|PubMed:12235138"
SQ SEQUENCE 138 AA; 15291 MW; 34A9A04735276A16 CRC64;
MILQQPLQRG PQGGAQRLPR AALGVTWGLD ASSPLRGAVP MSTKRRLEEE QEPLRKQFLS
EENMATHFSQ LSLHNDHPYC SPPMTFSPAL PPLRSPCSEL LLWRYPGSLI PEALRLLRLG
DTPSPPYPAT PAGDIMEL
