HPIP_MOUSE
ID HPIP_MOUSE Reviewed; 120 AA.
AC Q9CYQ5;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Host cell factor C1 regulator 1;
DE AltName: Full=HCF-1 beta-propeller-interacting protein;
GN Name=Hcfc1r1; Synonyms=Hpip;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Regulates HCFC1 activity by modulating its subcellular
CC localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1
CC in the cytoplasm. HCFC1R1-mediated export may provide the pool of
CC cytoplasmic HCFC1 required for import of virion-derived VP16 into the
CC nucleus (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with HCFC1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent
CC manner. {ECO:0000250}.
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DR EMBL; BC079865; AAH79865.1; -; mRNA.
DR EMBL; AK013438; BAB28855.1; -; mRNA.
DR CCDS; CCDS28455.1; -.
DR RefSeq; NP_861542.1; NM_181821.1.
DR AlphaFoldDB; Q9CYQ5; -.
DR STRING; 10090.ENSMUSP00000024697; -.
DR PhosphoSitePlus; Q9CYQ5; -.
DR PaxDb; Q9CYQ5; -.
DR PRIDE; Q9CYQ5; -.
DR ProteomicsDB; 273315; -.
DR Antibodypedia; 42633; 106 antibodies from 15 providers.
DR DNASU; 353502; -.
DR Ensembl; ENSMUST00000024697; ENSMUSP00000024697; ENSMUSG00000023904.
DR Ensembl; ENSMUST00000180140; ENSMUSP00000137336; ENSMUSG00000023904.
DR GeneID; 353502; -.
DR KEGG; mmu:353502; -.
DR UCSC; uc008asu.1; mouse.
DR CTD; 54985; -.
DR MGI; MGI:2663619; Hcfc1r1.
DR VEuPathDB; HostDB:ENSMUSG00000023904; -.
DR eggNOG; ENOG502SWHU; Eukaryota.
DR GeneTree; ENSGT00390000015785; -.
DR InParanoid; Q9CYQ5; -.
DR OMA; EDNMATH; -.
DR OrthoDB; 1435515at2759; -.
DR PhylomeDB; Q9CYQ5; -.
DR TreeFam; TF338381; -.
DR BioGRID-ORCS; 353502; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Hcfc1r1; mouse.
DR PRO; PR:Q9CYQ5; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9CYQ5; protein.
DR Bgee; ENSMUSG00000023904; Expressed in aorta tunica media and 263 other tissues.
DR ExpressionAtlas; Q9CYQ5; baseline and differential.
DR Genevisible; Q9CYQ5; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR InterPro; IPR029195; HCFC1R1.
DR PANTHER; PTHR16246; PTHR16246; 2.
DR Pfam; PF15226; HPIP; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..120
FT /note="Host cell factor C1 regulator 1"
FT /id="PRO_0000338979"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..61
FT /note="Interaction with HCFC1"
FT /evidence="ECO:0000250"
FT MOTIF 92..101
FT /note="Nuclear export signal"
FT /evidence="ECO:0000250"
SQ SEQUENCE 120 AA; 13359 MW; F48B630F567CFAC0 CRC64;
MILQQPLERG PPSRDPRATT GVTRGLNASL SPREPLHKQF LSEENMATHF SRLSLHNDHP
YCSPPVTFPE ALPPLRSPCP ELLLWRYPGS LIPEALRLLR LGDTPSPYYP ASPAGDIVEL
