ID   HPIP_RAT                Reviewed;         116 AA.
AC   Q80V38;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Host cell factor C1 regulator 1;
DE   AltName: Full=HCF-1 beta-propeller-interacting protein;
DE   AltName: Full=Inhibitor of four 2;
GN   Name=Hcfc1r1; Synonyms=Hpip;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 6-116.
RC   STRAIN=Sprague-Dawley; TISSUE=Sensory ganglion;
RA   Ellison A.R., Yang L., Bodeker M., Matthews P., Pakpour N., Margolis T.P.;
RT   "Functional cloning of neuronal genes that inhibit herpes simplex virus
RT   type 1 IE3 promoter activity.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates HCFC1 activity by modulating its subcellular
CC       localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1
CC       in the cytoplasm. HCFC1R1-mediated export may provide the pool of
CC       cytoplasmic HCFC1 required for import of virion-derived VP16 into the
CC       nucleus (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with HCFC1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent
CC       manner. {ECO:0000250}.
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DR   EMBL; CH473948; EDM03759.1; -; Genomic_DNA.
DR   EMBL; AY245001; AAO92641.1; -; mRNA.
DR   RefSeq; NP_001093962.1; NM_001100492.1.
DR   RefSeq; NP_001171976.1; NM_001185047.1.
DR   AlphaFoldDB; Q80V38; -.
DR   PaxDb; Q80V38; -.
DR   GeneID; 287097; -.
DR   KEGG; rno:287097; -.
DR   UCSC; RGD:727975; rat.
DR   CTD; 54985; -.
DR   RGD; 727975; Hcfc1r1.
DR   eggNOG; ENOG502SWHU; Eukaryota.
DR   InParanoid; Q80V38; -.
DR   OrthoDB; 1435515at2759; -.
DR   PRO; PR:Q80V38; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Proteomes; UP000234681; Chromosome 10.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029195; HCFC1R1.
DR   PANTHER; PTHR16246; PTHR16246; 2.
DR   Pfam; PF15226; HPIP; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..116
FT                   /note="Host cell factor C1 regulator 1"
FT                   /id="PRO_0000338980"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          54..57
FT                   /note="Interaction with HCFC1"
FT                   /evidence="ECO:0000250"
FT   MOTIF           88..97
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   116 AA;  12991 MW;  D296B40E29C64692 CRC64;
     MILQQPLERG PPGRDPRATT GVTLGLDTRE PLHKHFLSEE NMATHFSRLS LHNDHPYCSP
     PVTFPEALPP LRSPCPELLL WRYPGSLIPE ALRLLRLGDN PSPYYSASPA GEIMEL