HPLN3_MOUSE
ID HPLN3_MOUSE Reviewed; 359 AA.
AC Q80WM5; Q3UVT2; Q80XX3;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Hyaluronan and proteoglycan link protein 3;
DE Flags: Precursor;
GN Name=Hapln3; Synonyms=Lpr3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:AAP22049.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAP22049.1};
RX PubMed=12663660; DOI=10.1074/jbc.m213100200;
RA Spicer A.P., Joo A., Bowling R.A. Jr.;
RT "A hyaluronan binding link protein gene family whose members are physically
RT linked adjacent to chondroitin sulfate proteoglycan core protein genes: the
RT missing links.";
RL J. Biol. Chem. 278:21083-21091(2003).
RN [2] {ECO:0000312|EMBL:AAP12624.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ {ECO:0000312|EMBL:AAP12624.1};
RC TISSUE=Brain {ECO:0000312|EMBL:AAP12624.1};
RA Czipri M., Nesterovitch A.B., Glant T.T.;
RT "Discoordinate expression of link proteins and skeletal tissue
RT proteoglycans (aggrecan and versican) in different organs from early
RT embryonic to adult age of mice.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4] {ECO:0000312|EMBL:AAP12624.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May function in hyaluronic acid binding.
CC {ECO:0000303|PubMed:12663660}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HAPLN family. {ECO:0000305}.
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DR EMBL; AY262757; AAP22049.1; -; mRNA.
DR EMBL; AY269788; AAP12624.1; -; mRNA.
DR EMBL; AK136956; BAE23187.1; -; mRNA.
DR EMBL; CH466543; EDL07078.1; -; Genomic_DNA.
DR CCDS; CCDS21378.1; -.
DR RefSeq; NP_839986.2; NM_178255.3.
DR RefSeq; XP_006541190.1; XM_006541127.3.
DR RefSeq; XP_006541191.1; XM_006541128.3.
DR AlphaFoldDB; Q80WM5; -.
DR SMR; Q80WM5; -.
DR STRING; 10090.ENSMUSP00000032827; -.
DR PhosphoSitePlus; Q80WM5; -.
DR PaxDb; Q80WM5; -.
DR PRIDE; Q80WM5; -.
DR ProteomicsDB; 273271; -.
DR Antibodypedia; 28522; 115 antibodies from 21 providers.
DR DNASU; 67666; -.
DR Ensembl; ENSMUST00000206092; ENSMUSP00000146090; ENSMUSG00000030606.
DR GeneID; 67666; -.
DR KEGG; mmu:67666; -.
DR UCSC; uc009hxy.1; mouse.
DR CTD; 145864; -.
DR MGI; MGI:1914916; Hapln3.
DR VEuPathDB; HostDB:ENSMUSG00000030606; -.
DR eggNOG; ENOG502QWFF; Eukaryota.
DR GeneTree; ENSGT00940000159628; -.
DR HOGENOM; CLU_052285_1_0_1; -.
DR InParanoid; Q80WM5; -.
DR OMA; RPNCGSL; -.
DR OrthoDB; 743812at2759; -.
DR PhylomeDB; Q80WM5; -.
DR TreeFam; TF332134; -.
DR BioGRID-ORCS; 67666; 0 hits in 73 CRISPR screens.
DR PRO; PR:Q80WM5; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q80WM5; protein.
DR Bgee; ENSMUSG00000030606; Expressed in yolk sac and 59 other tissues.
DR ExpressionAtlas; Q80WM5; baseline and differential.
DR Genevisible; Q80WM5; MM.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005540; F:hyaluronic acid binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0001501; P:skeletal system development; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.10.100.10; -; 2.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000538; Link_dom.
DR Pfam; PF07686; V-set; 1.
DR Pfam; PF00193; Xlink; 2.
DR PRINTS; PR01265; LINKMODULE.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00445; LINK; 2.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF56436; SSF56436; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS01241; LINK_1; 2.
DR PROSITE; PS50963; LINK_2; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Extracellular matrix; Hyaluronic acid;
KW Immunoglobulin domain; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..359
FT /note="Hyaluronan and proteoglycan link protein 3"
FT /evidence="ECO:0000255"
FT /id="PRO_0000013191"
FT DOMAIN 48..164
FT /note="Ig-like V-type"
FT /evidence="ECO:0000305"
FT DOMAIN 166..261
FT /note="Link 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00323,
FT ECO:0000305"
FT DOMAIN 266..357
FT /note="Link 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00323,
FT ECO:0000305"
FT DISULFID 70..146
FT /evidence="ECO:0000250|UniProtKB:P03994"
FT DISULFID 188..259
FT /evidence="ECO:0000250|UniProtKB:P03994"
FT DISULFID 212..233
FT /evidence="ECO:0000250|UniProtKB:P03994"
FT DISULFID 286..355
FT /evidence="ECO:0000250|UniProtKB:P03994"
FT DISULFID 311..332
FT /evidence="ECO:0000250|UniProtKB:P03994"
FT CONFLICT 12
FT /note="F -> L (in Ref. 2; AAP12624)"
FT /evidence="ECO:0000305"
FT CONFLICT 29..31
FT /note="DLS -> GLR (in Ref. 2; AAP12624)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 359 AA; 40740 MW; 81E8F78DA76BB1E3 CRC64;
MSLLFLVLLS PFPCVLGLPF YNGFYYSNDL SGRTLGNGYG EGLFNGVKLV VETTEESLFS
HQGASVTLPC HYHYEPALAS PRHVRVKWWK LSENGAPEQD VLVVIGQRHR SFGDYQGRVQ
LRQDKQQEVS LELRDLRLED SGRYRCEVID GLEDESGLVE LELRGVVFPY QSREGRYQLN
FHEAQQACQE QGAMVATFEQ LFRAWEEGLD WCNAGWLQDA SVQYPIVLPR QPCGGLGLAP
GVRSYGQRHH RLHRYDVFCF AAALKGRVYY LENPKKLTLL EAREACQEDG AQISTVGQLF
AAWKFRGLDR CDAGWLADGS ARYPIVHPRL NCGPPEPGVR TFGFPDPHTR YGVYCYVQH
