ID   HPN_HELPJ               Reviewed;          60 AA.
AC   P0A0V7; Q48251;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Histidine-rich metal-binding polypeptide;
GN   Name=hpn; OrderedLocusNames=jhp_1320;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: Strongly binds nickel and zinc. Binds other metals less
CC       strongly: cobalt > copper > cadmium > manganese. May act to increase,
CC       or at least to preserve, urease activity. Exact function is still
CC       unknown (By similarity). {ECO:0000250}.
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DR   EMBL; AE001439; AAD06898.1; -; Genomic_DNA.
DR   PIR; C64698; C64698.
DR   AlphaFoldDB; P0A0V7; -.
DR   EnsemblBacteria; AAD06898; AAD06898; jhp_1320.
DR   KEGG; hpj:jhp_1320; -.
DR   OMA; HYHSHCH; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Metal-binding; Nickel; Repeat; Zinc.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..60
FT                   /note="Histidine-rich metal-binding polypeptide"
FT                   /id="PRO_0000084043"
FT   REPEAT          38..42
FT                   /note="1"
FT   REPEAT          51..55
FT                   /note="2"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          38..55
FT                   /note="2 X 5 AA repeats of E-E-G-C-C"
FT   COMPBIAS        8..31
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   60 AA;  7077 MW;  C3AEE3BB4FECDA71 CRC64;
     MAHHEEQHGG HHHHHHHTHH HHYHGGEHHH HHHSSHHEEG CCSTSDSHHQ EEGCCHGHHE