ID   HPO40_CAEEL             Reviewed;         782 AA.
AC   Q23647;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Hypersensitive to pore-forming toxin protein 40 {ECO:0000312|WormBase:ZK856.12};
GN   Name=hpo-40 {ECO:0000312|WormBase:ZK856.12};
GN   ORFNames=ZK856.12 {ECO:0000312|WormBase:ZK856.12};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION, AND DOMAIN.
RX   PubMed=32338603; DOI=10.7554/elife.56731;
RA   Manage K.I., Rogers A.K., Wallis D.C., Uebel C.J., Anderson D.C.,
RA   Nguyen D.A.H., Arca K., Brown K.C., Cordeiro Rodrigues R.J.,
RA   de Albuquerque B.F.M., Ketting R.F., Montgomery T.A., Phillips C.M.;
RT   "A Tudor domain protein, SIMR-1, promotes siRNA production at piRNA-
RT   targeted mRNAs in C. elegans.";
RL   Elife 9:0-0(2020).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000269|PubMed:32338603}. Note=Localizes to perinuclear foci in
CC       germ cells (PubMed:32338603). Its localization at perinuclear foci is
CC       either adjacent to or co-localized with mutator complex protein mut-16
CC       (PubMed:32338603). {ECO:0000269|PubMed:32338603}.
CC   -!- DOMAIN: Tudor domain specifically binds peptides with symmetrically
CC       dimethylated arginines (sDMA) and may facilitate protein-protein
CC       interactions. {ECO:0000303|PubMed:32338603}.
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DR   EMBL; BX284605; CAA94860.2; -; Genomic_DNA.
DR   PIR; T28051; T28051.
DR   RefSeq; NP_505628.2; NM_073227.3.
DR   AlphaFoldDB; Q23647; -.
DR   STRING; 6239.ZK856.12.1; -.
DR   EPD; Q23647; -.
DR   PaxDb; Q23647; -.
DR   PeptideAtlas; Q23647; -.
DR   EnsemblMetazoa; ZK856.12.1; ZK856.12.1; WBGene00014113.
DR   GeneID; 179421; -.
DR   KEGG; cel:CELE_ZK856.12; -.
DR   UCSC; ZK856.12; c. elegans.
DR   CTD; 179421; -.
DR   WormBase; ZK856.12; CE41097; WBGene00014113; hpo-40.
DR   eggNOG; ENOG502RT5V; Eukaryota.
DR   GeneTree; ENSGT00970000196511; -.
DR   HOGENOM; CLU_358340_0_0_1; -.
DR   InParanoid; Q23647; -.
DR   OMA; YPCALHC; -.
DR   OrthoDB; 1712752at2759; -.
DR   PhylomeDB; Q23647; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00014113; Expressed in adult organism and 3 other tissues.
DR   GO; GO:1990633; C:mutator focus; IDA:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
PE   4: Predicted;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..782
FT                   /note="Hypersensitive to pore-forming toxin protein 40"
FT                   /id="PRO_0000450824"
FT   DOMAIN          138..203
FT                   /note="Tudor; degenerate"
FT                   /evidence="ECO:0000305|PubMed:32338603"
FT   REGION          332..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          413..448
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          472..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          617..672
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        332..349
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        617..633
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        637..666
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   782 AA;  87435 MW;  BAA3ACD993E44C6B CRC64;
     MNSQQEWEHA YSLAERMYNK QAPTKREELN PTERVICSRF ETIFDYDPFK DEYTFRDQAL
     LFSTPVQPKC RTVAEADLHE LKENTAKLNI PMPSYINICP IYALLPFTVL VFNNSQHAHK
     SLSDDMERAA ATFRNPHESE IVPGAMYIFK QKHGKAYRCI ILSEDGDMNI PDAERKYLVA
     FIDNVQIVSV KQKTLFVSDQ FSIKDYPCAL HCARIVGISA IRKSYVSGMN QFILNFYDAK
     EKRKAGMFAF IYKLDKEEKK LVIDYPSLLG TPKTTSTEIR TAVGHQIVAS KDPVSLTFEQ
     LNKKEVPEFK YLNSTDDDSD VELDLIEHDT KSVNPVASSH PTSSSMDDCP YGRASIARAK
     DYQLRLPPHS QKGLSSSSLL GSSYPVSNSI KNDITKQSES NRADATNISF SSFESTKSDI
     SPQNNQNVEE TSTPTVPPNS TIQENEEDEI MSPASIIRAP SRLAGSLNKV SIERPNTPLP
     TSSKNSEHNM SEISTYEASS ISSHHLVPQS PSVPKTNYTV PVVQRPLTAP EKFRDPFGGP
     GSSDILNTKM LCSEKNIVPS NKFGRQISPG KDDKNENYQY SRMETKPQTL FAPVLDENQR
     QSSSSNMMCQ IPDISSVAQG SNAPKTAPND SVNSVAPDDI HETDKRGNHC KSVTEDPKDN
     KDPTAVTTLE DPDINDENFS VQSICSETFV ETDQKLMEVE TGADAFTESI TDQFAQMSEG
     LKKLAINLAD SVRTAAIEKN HDAFIANIHA MEIISKKVPD DIDKRFWKMK IVEARKLEAA
     FD