HPPD_CAEBR
ID HPPD_CAEBR Reviewed; 393 AA.
AC Q60Y65; A8XSJ1;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=4-hydroxyphenylpyruvate dioxygenase;
DE EC=1.13.11.27;
DE AltName: Full=4-hydroxyphenylpyruvic acid oxidase;
DE Short=4HPPD;
DE Short=HPD;
DE Short=HPPDase;
GN Name=hpd-1; ORFNames=CBG18361;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Key enzyme in the degradation of tyrosine. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate;
CC Xref=Rhea:RHEA:16189, ChEBI:CHEBI:15379, ChEBI:CHEBI:16169,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:36242; EC=1.13.11.27;
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC Note=Binds 1 Fe cation per subunit. {ECO:0000250};
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 3/6.
CC -!- SIMILARITY: Belongs to the 4HPPD family. {ECO:0000305}.
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DR EMBL; HE600936; CAP35833.1; -; Genomic_DNA.
DR RefSeq; XP_002642363.1; XM_002642317.1.
DR AlphaFoldDB; Q60Y65; -.
DR SMR; Q60Y65; -.
DR STRING; 6238.CBG18361; -.
DR EnsemblMetazoa; CBG18361.1; CBG18361.1; WBGene00037803.
DR GeneID; 8584357; -.
DR KEGG; cbr:CBG_18361; -.
DR CTD; 8584357; -.
DR WormBase; CBG18361; CBP04281; WBGene00037803; Cbr-hpd-1.
DR eggNOG; KOG0638; Eukaryota.
DR HOGENOM; CLU_034004_3_1_1; -.
DR InParanoid; Q60Y65; -.
DR OMA; DPFPVKG; -.
DR OrthoDB; 1087836at2759; -.
DR UniPathway; UPA00139; UER00362.
DR Proteomes; UP000008549; Chromosome III.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006572; P:tyrosine catabolic process; ISS:UniProtKB.
DR CDD; cd07250; HPPD_C_like; 1.
DR CDD; cd08342; HPPD_N_like; 1.
DR Gene3D; 3.10.180.10; -; 2.
DR InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR InterPro; IPR041735; 4OHPhenylPyrv_dOase_C.
DR InterPro; IPR041736; 4OHPhenylPyrv_dOase_N.
DR InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR InterPro; IPR037523; VOC.
DR PANTHER; PTHR11959; PTHR11959; 1.
DR Pfam; PF00903; Glyoxalase; 1.
DR PIRSF; PIRSF009283; HPP_dOase; 1.
DR SUPFAM; SSF54593; SSF54593; 1.
DR TIGRFAMs; TIGR01263; 4HPPD; 1.
DR PROSITE; PS51819; VOC; 2.
PE 3: Inferred from homology;
KW Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism;
KW Reference proteome; Repeat; Tyrosine catabolism.
FT CHAIN 1..393
FT /note="4-hydroxyphenylpyruvate dioxygenase"
FT /id="PRO_0000088394"
FT DOMAIN 17..148
FT /note="VOC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT DOMAIN 179..339
FT /note="VOC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT BINDING 182
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 267
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 350
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
SQ SEQUENCE 393 AA; 44600 MW; 8A5C3CAF60DF0B42 CRC64;
MTTFDRGEKP DIGTLVAFDH VRFVVGNAKQ AAYWYCANFG FEPFAYKGLE TGSRITAQHA
IKQDKIVFVF ESALLPDNTE LGEHLVQHGD GVKDVCFEVE DLDSIVAHAK AAGATIVRDI
TEESDENGSV RFATLRTYGE TDHTLLERKK YKGAFLPGFK PHPMPPTFFH SLPRVGLNFL
DHCVGNQPDL QMAPAVEWYE NILKFHRFWS VDDSMIHTEY SALRSIVVTN FEETIKMPIN
EPASSNKKAV SQIQEFVDYY GGSGVQHIAL NTTDIITAIE ALRARGCEFL SIPSSYYDNL
RQRLSVSSMK IKEDMDRLQK LHILVDFDEN GYLLQIFSKP CQDRPTLFLE IIQRQNHQGF
GAGNFKALFE SIELEQTKRG NLFYENVKDG QHK