HPPD_COCIM
ID HPPD_COCIM Reviewed; 399 AA.
AC Q1E803; J3KJ53; Q400Q2; Q9C0M8;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=4-hydroxyphenylpyruvate dioxygenase;
DE Short=4HPPD;
DE Short=HPD;
DE Short=HPPDase;
DE EC=1.13.11.27;
DE AltName: Full=T-cell reactive protein;
GN Name=TCRP; ORFNames=CIMG_01310;
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=RS;
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 233-362.
RC STRAIN=RMSCC 2267 / CA1;
RX PubMed=9144263; DOI=10.1073/pnas.94.10.5478;
RA Koufopanou V., Burt A., Taylor J.W.;
RT "Concordance of gene genealogies reveals reproductive isolation in the
RT pathogenic fungus Coccidioides immitis.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:5478-5482(1997).
RN [4]
RP ERRATUM OF PUBMED:9144263.
RA Koufopanou V., Burt A., Taylor J.W.;
RL Proc. Natl. Acad. Sci. U.S.A. 95:8414-8414(1998).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 237-383.
RC STRAIN=IFM 45815, IFM 45816, IFM 46868, IFM 50992, and IFM 50995;
RX PubMed=16699492; DOI=10.3314/jjmm.47.113;
RA Sano A., Miyaji M., Kamei K., Mikami Y., Nishimura K.;
RT "Reexamination of Coccidioides spp. reserved in the Research Center for
RT Pathogenic Fungi and Microbial Toxicoses, Chiba University, based on a
RT multiple gene analysis.";
RL Nippon Ishinkin Gakkai Zasshi 47:113-117(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate;
CC Xref=Rhea:RHEA:16189, ChEBI:CHEBI:15379, ChEBI:CHEBI:16169,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:36242; EC=1.13.11.27;
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC Note=Binds 1 Fe cation per subunit. {ECO:0000250};
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 3/6.
CC -!- SIMILARITY: Belongs to the 4HPPD family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE20316.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAE20317.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAE20319.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAE20320.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAE20323.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; GG704911; EAS35956.3; -; Genomic_DNA.
DR EMBL; AJ291969; CAC35134.1; -; Genomic_DNA.
DR EMBL; AB232871; BAE20316.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB232872; BAE20317.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB232874; BAE20319.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB232875; BAE20320.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB232878; BAE20323.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001247539.1; XM_001247538.2.
DR AlphaFoldDB; Q1E803; -.
DR SMR; Q1E803; -.
DR STRING; 246410.Q1E803; -.
DR EnsemblFungi; EAS35956; EAS35956; CIMG_01310.
DR GeneID; 4567103; -.
DR KEGG; cim:CIMG_01310; -.
DR VEuPathDB; FungiDB:CIMG_01310; -.
DR InParanoid; Q1E803; -.
DR OMA; DPFPVKG; -.
DR OrthoDB; 1087836at2759; -.
DR UniPathway; UPA00139; UER00362.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR CDD; cd07250; HPPD_C_like; 1.
DR CDD; cd08342; HPPD_N_like; 1.
DR Gene3D; 3.10.180.10; -; 2.
DR InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR InterPro; IPR041735; 4OHPhenylPyrv_dOase_C.
DR InterPro; IPR041736; 4OHPhenylPyrv_dOase_N.
DR InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR InterPro; IPR037523; VOC.
DR PANTHER; PTHR11959; PTHR11959; 1.
DR Pfam; PF00903; Glyoxalase; 1.
DR PIRSF; PIRSF009283; HPP_dOase; 1.
DR SUPFAM; SSF54593; SSF54593; 1.
DR TIGRFAMs; TIGR01263; 4HPPD; 1.
DR PROSITE; PS51819; VOC; 2.
PE 3: Inferred from homology;
KW Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism;
KW Reference proteome; Repeat; Tyrosine catabolism.
FT CHAIN 1..399
FT /note="4-hydroxyphenylpyruvate dioxygenase"
FT /id="PRO_0000252281"
FT DOMAIN 23..166
FT /note="VOC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT DOMAIN 197..355
FT /note="VOC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT BINDING 200
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 283
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 366
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
SQ SEQUENCE 399 AA; 45290 MW; 7C440F0B51E82BA3 CRC64;
MAPAADSPTL QPAQPSDLNQ YRGYDHVHWY VGNAKQAATY YVTRMGFERV AYRGLETGSK
AVASHVVRNG NITFILTSPL RSVEQASRFP EDEALLKEIH AHLERHGDGV KDVAFEVDCV
ESVFSAAVRN GAEVVSDVRT VEDEDGQIKM ATIRTYGETT HTLIERSGYR GGFMPGYRME
SNVDATSKFL PKVVLERIDH CVGNQDWDEM ERVCDYYEKI LGFHRFWSVD DKDICTEFSA
LKSIVMASPN DIVKMPINEP AKGKKQSQIE EYVDFYNGAG VQHIALRTNN IIDAITNLKA
RGTEFIKVPE TYYEDMKIRL KRQGLVLDED FETLKSLDIL IDFDENGYLL QLFTKHLMDR
PTVFIEIIQR NNFSGFGAGN FRALFEAIER EQALRGTLI
