HPPD_COCPS
ID HPPD_COCPS Reviewed; 399 AA.
AC E9CWP5; C5PGS8; Q00415; Q02288; Q400Q0; Q400Q8; Q9C0M8;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 37.
DE RecName: Full=4-hydroxyphenylpyruvate dioxygenase;
DE Short=4HPPD;
DE Short=HPD;
DE Short=HPPDase;
DE EC=1.13.11.27;
DE AltName: Full=T-cell reactive protein;
GN Name=TCRP; ORFNames=CPSG_01878;
OS Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=443226;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Coccidioides posadasii strain Silveira.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 233-362.
RC STRAIN=RMSCC 757 / Silveira;
RX PubMed=9144263; DOI=10.1073/pnas.94.10.5478;
RA Koufopanou V., Burt A., Taylor J.W.;
RT "Concordance of gene genealogies reveals reproductive isolation in the
RT pathogenic fungus Coccidioides immitis.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:5478-5482(1997).
RN [3]
RP ERRATUM OF PUBMED:9144263.
RA Koufopanou V., Burt A., Taylor J.W.;
RL Proc. Natl. Acad. Sci. U.S.A. 95:8414-8414(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 237-383, AND VARIANT SER-250.
RC STRAIN=IFM 45809 / Silveira, IFM 45810 / Silveira, IFM 45811, IFM 45812,
RC IFM 45813, IFM 45817, IFM 4935, IFM 4945, IFM 50993, IFM 50994, IFM 51112,
RC IFM 54194, IFM 54195, and IFM 54196;
RX PubMed=16699492; DOI=10.3314/jjmm.47.113;
RA Sano A., Miyaji M., Kamei K., Mikami Y., Nishimura K.;
RT "Reexamination of Coccidioides spp. reserved in the Research Center for
RT Pathogenic Fungi and Microbial Toxicoses, Chiba University, based on a
RT multiple gene analysis.";
RL Nippon Ishinkin Gakkai Zasshi 47:113-117(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate;
CC Xref=Rhea:RHEA:16189, ChEBI:CHEBI:15379, ChEBI:CHEBI:16169,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:36242; EC=1.13.11.27;
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC Note=Binds 1 Fe cation per subunit. {ECO:0000250};
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 3/6.
CC -!- SIMILARITY: Belongs to the 4HPPD family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE20309.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAE20310.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAE20311.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAE20312.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAE20313.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAE20314.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAE20315.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAE20318.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAE20321.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAE20322.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAE20324.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAE20325.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAE20326.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAE20327.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; GL636487; EFW21721.1; -; Genomic_DNA.
DR EMBL; AJ291968; CAC35132.1; -; Genomic_DNA.
DR EMBL; AB232864; BAE20309.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB232865; BAE20310.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB232866; BAE20311.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB232867; BAE20312.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB232868; BAE20313.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB232869; BAE20314.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB232870; BAE20315.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB232873; BAE20318.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB232876; BAE20321.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB232877; BAE20322.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB232879; BAE20324.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB232880; BAE20325.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB232881; BAE20326.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB232882; BAE20327.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; E9CWP5; -.
DR SMR; E9CWP5; -.
DR STRING; 443226.E9CWP5; -.
DR EnsemblFungi; EFW21721; EFW21721; CPSG_01878.
DR VEuPathDB; FungiDB:CPSG_01878; -.
DR eggNOG; KOG0638; Eukaryota.
DR HOGENOM; CLU_034004_3_1_1; -.
DR UniPathway; UPA00139; UER00362.
DR Proteomes; UP000002497; Unassembled WGS sequence.
DR GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR CDD; cd07250; HPPD_C_like; 1.
DR CDD; cd08342; HPPD_N_like; 1.
DR Gene3D; 3.10.180.10; -; 2.
DR InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR InterPro; IPR041735; 4OHPhenylPyrv_dOase_C.
DR InterPro; IPR041736; 4OHPhenylPyrv_dOase_N.
DR InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR InterPro; IPR037523; VOC.
DR PANTHER; PTHR11959; PTHR11959; 1.
DR Pfam; PF00903; Glyoxalase; 1.
DR PIRSF; PIRSF009283; HPP_dOase; 1.
DR SUPFAM; SSF54593; SSF54593; 1.
DR TIGRFAMs; TIGR01263; 4HPPD; 1.
DR PROSITE; PS51819; VOC; 2.
PE 3: Inferred from homology;
KW Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism;
KW Reference proteome; Repeat; Tyrosine catabolism.
FT CHAIN 1..399
FT /note="4-hydroxyphenylpyruvate dioxygenase"
FT /id="PRO_0000409488"
FT DOMAIN 23..166
FT /note="VOC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT DOMAIN 197..355
FT /note="VOC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT BINDING 200
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 283
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 366
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT VARIANT 250
FT /note="N -> S (in strain: IFM 45817)"
FT /evidence="ECO:0000269|PubMed:16699492"
SQ SEQUENCE 399 AA; 45262 MW; 342DEFF33091C3C2 CRC64;
MAPAADSPTL QPAQPSDLNQ YRGYDHVHWY VGNAKQAATY YVTRMGFERV AYRGLETGSK
AVASHVVRNG NITFILTSPL RSVEQASRFP EDEALLKEIH AHLERHGDGV KDVAFEVDCV
ESVFSAAVRN GAEVVSDVRT VEDEDGQIKM ATIRTYGETT HTLIERSGYR GGFMPGYRME
SNADATSKFL PKVVLERIDH CVGNQDWDEM ERVCDYYEKI LGFHRFWSVD DKDICTEFSA
LKSIVMASPN DIVKMPINEP AKGKKQSQIE EYVDFYNGAG VQHIALRTNN IIDAITNLKA
RGTEFIKVPE TYYEDMKIRL KRQGLVLDED FETLKSLDIL IDFDENGYLL QLFTKHLMDR
PTVFIEIIQR NNFSGFGAGN FRALFEAIER EQALRGTLI
