ID   HPPD_MAGO7              Reviewed;         419 AA.
AC   Q96X22; A4R2B8; G4ML51;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=4-hydroxyphenylpyruvate dioxygenase;
DE            Short=4HPPD;
DE            Short=HPD;
DE            Short=HPPDase;
DE            EC=1.13.11.27;
GN   Name=HPD4; ORFNames=MGG_06691;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Guyane 11;
RX   PubMed=11296265; DOI=10.1073/pnas.091094198;
RA   Hamer L., Adachi K., Montenegro-Chamorro M.V., Tanzer M., Mahanty S.,
RA   Lo C., Tarpey R.W., Skalchunes A., Heiniger R., Frank S., Darveaux B.,
RA   Lampe D.J., Slater T., Ramamurthy L., Dezwaan T., Nelson G., Shuster J.,
RA   Woessner J., Hamer J.E.;
RT   "Gene discovery and gene function assignment in filamentous fungi.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:5110-5115(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate;
CC         Xref=Rhea:RHEA:16189, ChEBI:CHEBI:15379, ChEBI:CHEBI:16169,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:36242; EC=1.13.11.27;
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC       Note=Binds 1 Fe cation per subunit. {ECO:0000250};
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetate and fumarate from L-phenylalanine: step 3/6.
CC   -!- SIMILARITY: Belongs to the 4HPPD family. {ECO:0000305}.
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DR   EMBL; AF325533; AAK48714.1; -; Genomic_DNA.
DR   EMBL; CM001231; EHA56787.1; -; Genomic_DNA.
DR   RefSeq; XP_003709399.1; XM_003709351.1.
DR   AlphaFoldDB; Q96X22; -.
DR   SMR; Q96X22; -.
DR   STRING; 318829.MGG_06691T0; -.
DR   PRIDE; Q96X22; -.
DR   EnsemblFungi; MGG_06691T0; MGG_06691T0; MGG_06691.
DR   GeneID; 2684864; -.
DR   KEGG; mgr:MGG_06691; -.
DR   VEuPathDB; FungiDB:MGG_06691; -.
DR   eggNOG; KOG0638; Eukaryota.
DR   HOGENOM; CLU_034004_3_1_1; -.
DR   InParanoid; Q96X22; -.
DR   OMA; DPFPVKG; -.
DR   OrthoDB; 1087836at2759; -.
DR   UniPathway; UPA00139; UER00362.
DR   Proteomes; UP000009058; Chromosome 1.
DR   GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd07250; HPPD_C_like; 1.
DR   CDD; cd08342; HPPD_N_like; 1.
DR   Gene3D; 3.10.180.10; -; 2.
DR   InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR   InterPro; IPR041735; 4OHPhenylPyrv_dOase_C.
DR   InterPro; IPR041736; 4OHPhenylPyrv_dOase_N.
DR   InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR   InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR   InterPro; IPR037523; VOC.
DR   PANTHER; PTHR11959; PTHR11959; 1.
DR   Pfam; PF00903; Glyoxalase; 2.
DR   PIRSF; PIRSF009283; HPP_dOase; 1.
DR   SUPFAM; SSF54593; SSF54593; 1.
DR   TIGRFAMs; TIGR01263; 4HPPD; 1.
DR   PROSITE; PS51819; VOC; 2.
PE   3: Inferred from homology;
KW   Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism;
KW   Reference proteome; Repeat; Tyrosine catabolism.
FT   CHAIN           1..419
FT                   /note="4-hydroxyphenylpyruvate dioxygenase"
FT                   /id="PRO_0000088404"
FT   DOMAIN          37..185
FT                   /note="VOC 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT   DOMAIN          216..376
FT                   /note="VOC 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT   BINDING         219
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         302
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         387
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   419 AA;  47576 MW;  642BA6A96C4AFA76 CRC64;
     MSPSAITESP RNSVVDHTSG LQVDSLAVQG PFPSFHGYDH VTWWVGNAKQ AASYYNTLFG
     MKIIAYRGLE TGSRYFASYL VGKEDVRFVF TSPIRSHVHL PEDEPISDED RALLKEMHAH
     LEKHGDAVKD VCFEVDNVQG VYERAVQQGA VSIAPPKTLS DKEHGSVTMA VIQTYGDTTH
     TLLSRDNFRG TFLPGFRDVN RQPAAYSALA PVPLQRIDHC VGNQDWDDMR AACDFYERCL
     SFHRFWSVDD NQISTDFSAL NSIVMASPNN VVKMPINEPA KGKKRSQIEE YVTFNSGAGV
     QHIALLTSDI ITTVEAMRSR GVEFIEVPHT YYDTMRRRLK TEKRDWELQE DFDRLVRNNI
     LIDYDEGGYL LQLFTRPLMD RPTVFIEIIQ RNEFDGFGAG NFKSLFEAIE REQAERGNL