ID   HPR9_CAEEL              Reviewed;         521 AA.
AC   Q95Q27;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2016, sequence version 3.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Cell cycle checkpoint protein hpr-9 {ECO:0000305};
GN   Name=hpr-9 {ECO:0000312|WormBase:Y39A1A.23a};
GN   ORFNames=Y39A1A.23 {ECO:0000312|WormBase:Y39A1A.23a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, IDENTIFICATION IN THE 9-1-1 COMPLEX, AND DISRUPTION PHENOTYPE.
RX   PubMed=12445383; DOI=10.1016/s0960-9822(02)01262-9;
RA   Hofmann E.R., Milstein S., Boulton S.J., Ye M., Hofmann J.J., Stergiou L.,
RA   Gartner A., Vidal M., Hengartner M.O.;
RT   "Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required
RT   for genome stability and EGL-1-mediated apoptosis.";
RL   Curr. Biol. 12:1908-1918(2002).
CC   -!- FUNCTION: May be a component of the 9-1-1 cell-cycle checkpoint
CC       response complex that plays a major role in DNA repair.
CC       {ECO:0000305|PubMed:12445383}.
CC   -!- SUBUNIT: Putative component of the toroidal 9-1-1 (RAD9-RAD1-HUS1)
CC       complex, composed of hpr-9, mrt-2 and hus-1 (Probable).
CC       {ECO:0000305|PubMed:12445383}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown disrupts hus-1
CC       localization to the nucleus. {ECO:0000269|PubMed:12445383}.
CC   -!- SIMILARITY: Belongs to the rad9 family. {ECO:0000305}.
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DR   EMBL; BX284603; CAC42372.3; -; Genomic_DNA.
DR   RefSeq; NP_499342.3; NM_066941.6.
DR   AlphaFoldDB; Q95Q27; -.
DR   SMR; Q95Q27; -.
DR   ComplexPortal; CPX-1615; Checkpoint clamp complex.
DR   IntAct; Q95Q27; 2.
DR   MINT; Q95Q27; -.
DR   STRING; 6239.Y39A1A.23.1; -.
DR   EPD; Q95Q27; -.
DR   PaxDb; Q95Q27; -.
DR   EnsemblMetazoa; Y39A1A.23a.1; Y39A1A.23a.1; WBGene00001997.
DR   GeneID; 176483; -.
DR   KEGG; cel:CELE_Y39A1A.23; -.
DR   UCSC; Y39A1A.23.1; c. elegans.
DR   CTD; 176483; -.
DR   WormBase; Y39A1A.23a; CE51732; WBGene00001997; hpr-9.
DR   eggNOG; KOG2810; Eukaryota.
DR   GeneTree; ENSGT00390000005767; -.
DR   HOGENOM; CLU_479993_0_0_1; -.
DR   InParanoid; Q95Q27; -.
DR   OrthoDB; 975890at2759; -.
DR   Reactome; R-CEL-176187; Activation of ATR in response to replication stress.
DR   PRO; PR:Q95Q27; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00001997; Expressed in germ line (C elegans) and 4 other tissues.
DR   ExpressionAtlas; Q95Q27; baseline and differential.
DR   GO; GO:0030896; C:checkpoint clamp complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IC:ComplexPortal.
DR   GO; GO:0071479; P:cellular response to ionizing radiation; IBA:GO_Central.
DR   GO; GO:0000077; P:DNA damage checkpoint signaling; IC:ComplexPortal.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0000076; P:DNA replication checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IBA:GO_Central.
DR   InterPro; IPR007268; Rad9/Ddc1.
DR   PANTHER; PTHR15237; PTHR15237; 1.
DR   Pfam; PF04139; Rad9; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..521
FT                   /note="Cell cycle checkpoint protein hpr-9"
FT                   /id="PRO_0000441109"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          318..375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          492..521
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        318..336
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        337..372
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   521 AA;  59462 MW;  54330A048C4E68C8 CRC64;
     MQAIHENYTD NPSSSITRER QHEDMKGAQF VVQSNLKIMS RSIAALSKIS EDVLIEVSEG
     GLFFKTVNRS KFCVFRFAPE FFNACDVSMI NKKAVNICRL SMKSAQRIFK GVAFGEKNFV
     GCEFRIDPKA ERMMVKLQMN YDIERTIHAK LREMGSMLHK PTYNRSGCRN ITVVFASTLL
     PIFVQMKGDI EVTMKVTDDG LTIRNFHSLD GVTMFNMGVE KGAKKVKTET TITCEKLTRH
     KIQIPVEFSF SIKEFLSIVT FADQLGSEVC MYYDLPGKPL IVSIEAHPNF DIELALATMG
     SDDEIDLDGG ILKETMAQHE EEEDKSTAHS SSSRRKSKAI DTSSSGTQKS KKCSESLSQE
     ETTRSQSLPS RNRFVPEIPV AEQSWRDREV TVYEQREPSP DLQIVEEVME IDNQPIVTRT
     IKEEHSVEQA MQDVSIETIP VETPEENIIP VEVEMLEEPE QEDQEIFKIP QPKRRKTAED
     DRNRKIRRIL MGTETTSKMR MSQQFDKRLG PLVSDTQYES R