AP1B_DICDI
ID AP1B_DICDI Reviewed; 942 AA.
AC Q54X82;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=AP-1 complex subunit beta;
DE AltName: Full=Adaptor protein complex AP-1 subunit beta;
DE AltName: Full=Adaptor-related protein complex 1 subunit beta;
DE AltName: Full=Beta-1-adaptin;
DE AltName: Full=Beta-adaptin 1;
DE AltName: Full=Clathrin assembly protein complex 1 beta large chain;
GN Name=ap1b1; ORFNames=DDB_G0279141;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that
CC plays a role in protein sorting in the trans-Golgi network (TGN) and
CC endosomes. The AP complexes mediate the recruitment of clathrin to
CC membranes and the recognition of sorting signals within the cytosolic
CC tails of transmembrane cargo molecules. Also involved in early steps of
CC phagocytosis and macropinocytosis.
CC -!- SUBUNIT: Adaptor protein complex 1 (AP-1) is a heterotetramer composed
CC of two large adaptins (gamma-type subunit and beta-type subunit), a
CC medium adaptin (mu-type subunit) and a small adaptin (sigma-type
CC subunit). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network. Cytoplasmic
CC vesicle, clathrin-coated vesicle membrane {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000027; EAL67870.1; -; Genomic_DNA.
DR RefSeq; XP_641846.1; XM_636754.1.
DR AlphaFoldDB; Q54X82; -.
DR SMR; Q54X82; -.
DR STRING; 44689.DDB0234067; -.
DR PaxDb; Q54X82; -.
DR PRIDE; Q54X82; -.
DR EnsemblProtists; EAL67870; EAL67870; DDB_G0279141.
DR GeneID; 8621892; -.
DR KEGG; ddi:DDB_G0279141; -.
DR dictyBase; DDB_G0279141; ap1b1.
DR eggNOG; KOG1061; Eukaryota.
DR HOGENOM; CLU_006320_2_0_1; -.
DR InParanoid; Q54X82; -.
DR OMA; NPPEVQW; -.
DR PhylomeDB; Q54X82; -.
DR Reactome; R-DDI-432720; Lysosome Vesicle Biogenesis.
DR Reactome; R-DDI-437239; Recycling pathway of L1.
DR Reactome; R-DDI-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-DDI-8856828; Clathrin-mediated endocytosis.
DR Reactome; R-DDI-8866427; VLDLR internalisation and degradation.
DR Reactome; R-DDI-8964038; LDL clearance.
DR PRO; PR:Q54X82; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0030121; C:AP-1 adaptor complex; IDA:dictyBase.
DR GO; GO:0030122; C:AP-2 adaptor complex; IDA:dictyBase.
DR GO; GO:0030132; C:clathrin coat of coated pit; IC:dictyBase.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.
DR GO; GO:0033298; P:contractile vacuole organization; IMP:dictyBase.
DR GO; GO:0006971; P:hypotonic response; IMP:dictyBase.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0000281; P:mitotic cytokinesis; IMP:dictyBase.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 2.60.40.1150; -; 1.
DR Gene3D; 3.30.310.10; -; 1.
DR InterPro; IPR026739; AP_beta.
DR InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015151; B-adaptin_app_sub_C.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR013037; Clathrin_b-adaptin_app_Ig-like.
DR InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR11134; PTHR11134; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF09066; B2-adapt-app_C; 1.
DR PIRSF; PIRSF002291; AP_complex_beta; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM01020; B2-adapt-app_C; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF49348; SSF49348; 1.
DR SUPFAM; SSF55711; SSF55711; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Repeat; Transport.
FT CHAIN 1..942
FT /note="AP-1 complex subunit beta"
FT /id="PRO_0000328676"
FT REPEAT 45..82
FT /note="HEAT 1"
FT REPEAT 117..154
FT /note="HEAT 2"
FT REPEAT 156..193
FT /note="HEAT 3"
FT REPEAT 273..313
FT /note="HEAT 4"
FT REPEAT 384..421
FT /note="HEAT 5"
FT REPEAT 458..495
FT /note="HEAT 6"
FT REGION 590..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..650
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 942 AA; 106609 MW; 7CB62C24D53E6B33 CRC64;
MSDSKYFQTT KKGEIHELKE ELLSQREDKK KEAVKKVIAA MTVGKDVSML FTHVLNCMQT
HNLELKKLVY LYVMNYAKNH PDRAILAVNT FQKDASDPNP LIRALAVRTM GCIRVDNITE
HLCEPLRHAL KDQDPYVRKT AAVCVAKLYD VNPELVENQG FLNILNDLLG DSNPMVVANA
VASLTEIDEV SKKEVFRIHS GNLNKLLAAL NECTEWGQVF ILNSLCKYTP RDSQEAENVC
ERVAPRLQHA NSAVVLSAVK VLMKYMNSIG NNDVIRLFCK KMAPPLVTLL SKEPEIQFLG
LRNINLIVQK RPEILQYEMK VFFCKYNDPI YVKMEKLEIM IMLANEKNIE EVLLEFKEYA
TEIDVEFVRK AVRAIGRCAI KIDRASERCI QVLLDLIQTK VNYVVQEAII VIKDIFRKYP
NKYEGIIATL CANLESLDEP EAKASMIWII GEYAERIDNA HELLNSFLEG FKDENSQVQL
QLLTSIVKLF LKRPKDAQQM VQTVLNLSTQ ESDNPDLRDR GFVYWRLLST DFEAAKAVVL
SEKPLITDTT SHLDESLLNE LILNISTLAS VYHKPPETFV TKLKGLNKRG LRNKEEEDEE
EPDYVDDDNM NNQQGGQQQQ GGYQQQQQQQ QQGGYQQQQP QQQQPKSGNL IDLDLSDLGG
ALPNNNNNNY GNNNNNNMYS PQPQQFNGNS NDLSFLGGGG GGGEVQAPVN KVVVFGGDRS
QAIQISGAFT RFQGRINLEL NLLNTSQQGM SKFKIQFYQN SFGISPADQI LSCGAIEVGQ
STDVTIPISC NGQISNPLNP VIDMAMMVLP SQERFYFKMN FPLLCLLTET GRLDRESYLS
MWKSIPESNE RSVEIQVRLP HVDVDSILRR LNSKNIFEIV RKKAPNQEIS FLSCKTESSV
YILIELAFNI STNTCRCSSK TTSPDIMALF EHNLNLLINN QI
