ID   HPRL_NATPD              Reviewed;         189 AA.
AC   Q3IST1;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=HGPRTase-like protein {ECO:0000255|HAMAP-Rule:MF_01467};
DE            EC=2.4.2.- {ECO:0000255|HAMAP-Rule:MF_01467};
GN   OrderedLocusNames=NP_1426A;
OS   Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM
OS   8858 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Natronomonas.
OX   NCBI_TaxID=348780;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB
RC   2260 / Gabara;
RX   PubMed=16169924; DOI=10.1101/gr.3952905;
RA   Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J.,
RA   Oesterhelt D.;
RT   "Living with two extremes: conclusions from the genome sequence of
RT   Natronomonas pharaonis.";
RL   Genome Res. 15:1336-1343(2005).
CC   -!- FUNCTION: May catalyze a purine salvage reaction, the substrate is
CC       unknown. {ECO:0000255|HAMAP-Rule:MF_01467}.
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. Archaeal HPRT subfamily. {ECO:0000255|HAMAP-Rule:MF_01467}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR936257; CAI48804.1; -; Genomic_DNA.
DR   RefSeq; WP_011322439.1; NC_007426.1.
DR   AlphaFoldDB; Q3IST1; -.
DR   SMR; Q3IST1; -.
DR   STRING; 348780.NP_1426A; -.
DR   EnsemblBacteria; CAI48804; CAI48804; NP_1426A.
DR   GeneID; 3702512; -.
DR   KEGG; nph:NP_1426A; -.
DR   eggNOG; arCOG00030; Archaea.
DR   HOGENOM; CLU_126376_0_0_2; -.
DR   OMA; FIHPISD; -.
DR   OrthoDB; 88302at2157; -.
DR   Proteomes; UP000002698; Chromosome.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   HAMAP; MF_01467; Hypx_phosphoribosyltr; 1.
DR   InterPro; IPR026597; HGPRTase-like.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
DR   PROSITE; PS00103; PUR_PYR_PR_TRANSFER; 1.
PE   3: Inferred from homology;
KW   Purine salvage; Reference proteome; Transferase.
FT   CHAIN           1..189
FT                   /note="HGPRTase-like protein"
FT                   /id="PRO_0000415490"
SQ   SEQUENCE   189 AA;  20539 MW;  91D1A0F69896D735 CRC64;
     MDQLQQSLLE APIIEKDGYH YFVHPISDGV PMLEPNLLRE IVIKIIRKAQ LENVDKIVTP
     AAMGIHISTA VSLMTDIPLV VIRKREYGLD GETPLFQQTG YSENQMYIND VDEGDSVLVL
     DDVLSTGGTL SAICSALEDI GADIVDVVAV IKKVGGENEL ESSPYSAKTL INVDVEDGEV
     VIIDSNGDN