ID   HPR_ALKCK               Reviewed;         196 AA.
AC   Q5WHU1;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=HTH-type transcriptional regulator Hpr {ECO:0000255|HAMAP-Rule:MF_01911};
DE   AltName: Full=Protease production regulatory protein Hpr {ECO:0000255|HAMAP-Rule:MF_01911};
GN   Name=hpr {ECO:0000255|HAMAP-Rule:MF_01911}; OrderedLocusNames=ABC1529;
OS   Alkalihalobacillus clausii (strain KSM-K16) (Bacillus clausii).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=66692;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSM-K16;
RA   Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y.,
RA   Kawai S., Ito S., Horikoshi K.;
RT   "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-
RT   K16.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of protease production and sporulation.
CC       {ECO:0000255|HAMAP-Rule:MF_01911}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01911}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD64064.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AP006627; BAD64064.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_035204480.1; NC_006582.1.
DR   AlphaFoldDB; Q5WHU1; -.
DR   SMR; Q5WHU1; -.
DR   STRING; 66692.ABC1529; -.
DR   EnsemblBacteria; BAD64064; BAD64064; ABC1529.
DR   KEGG; bcl:ABC1529; -.
DR   eggNOG; COG1846; Bacteria.
DR   HOGENOM; CLU_115790_0_0_9; -.
DR   OrthoDB; 1744037at2; -.
DR   Proteomes; UP000001168; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01911; HTH_type_Hpr; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023488; HTH_tscrpt_reg_Hpr.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Sporulation; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..196
FT                   /note="HTH-type transcriptional regulator Hpr"
FT                   /id="PRO_0000343622"
FT   DOMAIN          13..157
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01911"
FT   DNA_BIND        63..86
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01911"
SQ   SEQUENCE   196 AA;  22734 MW;  36D0BB8526E72DD0 CRC64;
     MEEMDLNHPL KESIVFSHKM ALLSKALWKS VEKDWQAWIK PFHLNLNEHH ILWIAYQLNG
     ATISDIASHG VMHVSTAFNF SKKLEARGLL SFSKKKDDKR NTYICLTDSG RQLFLETMRA
     FNEHTYHVYQ GAVPMKELYG KFPEFSELIC IVRHIYGTEF IEQFDACLTD FQNDVEEKDG
     HLKLASANLF PLQPAK