HPR_ALKHC
ID HPR_ALKHC Reviewed; 192 AA.
AC Q9KDM7;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=HTH-type transcriptional regulator Hpr {ECO:0000255|HAMAP-Rule:MF_01911};
DE AltName: Full=Protease production regulatory protein Hpr {ECO:0000255|HAMAP-Rule:MF_01911};
GN Name=hpr {ECO:0000255|HAMAP-Rule:MF_01911}; OrderedLocusNames=BH1185;
OS Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS / JCM 9153 / C-125) (Bacillus halodurans).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=272558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
CC -!- FUNCTION: Negative regulator of protease production and sporulation.
CC {ECO:0000255|HAMAP-Rule:MF_01911}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01911}.
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DR EMBL; BA000004; BAB04904.1; -; Genomic_DNA.
DR PIR; A83798; A83798.
DR RefSeq; WP_010897354.1; NC_002570.2.
DR AlphaFoldDB; Q9KDM7; -.
DR SMR; Q9KDM7; -.
DR STRING; 272558.10173801; -.
DR EnsemblBacteria; BAB04904; BAB04904; BAB04904.
DR KEGG; bha:BH1185; -.
DR eggNOG; COG1846; Bacteria.
DR HOGENOM; CLU_115790_0_0_9; -.
DR OMA; EKDWQNW; -.
DR OrthoDB; 1744037at2; -.
DR Proteomes; UP000001258; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01911; HTH_type_Hpr; 1.
DR InterPro; IPR000835; HTH_MarR-typ.
DR InterPro; IPR023488; HTH_tscrpt_reg_Hpr.
DR InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF01047; MarR; 1.
DR SMART; SM00347; HTH_MARR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS01117; HTH_MARR_1; 1.
DR PROSITE; PS50995; HTH_MARR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..192
FT /note="HTH-type transcriptional regulator Hpr"
FT /id="PRO_0000343623"
FT DOMAIN 12..156
FT /note="HTH marR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01911"
FT DNA_BIND 62..85
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01911"
SQ SEQUENCE 192 AA; 22239 MW; 39C469E75C7CF8E7 CRC64;
MEQQTAYSLK QSIIFSHKFA QLSKALWKSV EKDWQTWIKP FNLNINEHHI LWITYHLDGA
SISDIAKFGV MHVSTAFNFS KKLEERGLLT FSKREHDKRN TYVDLTEQGR ELFLETLEAY
KPSTYSVYGG ALPIKDLYGK FPEFSELLSI VRHVYGPDFI DMFETALTRL EDGFIEEDGK
LKAVDSETKS TV