HPR_BACAA
ID HPR_BACAA Reviewed; 185 AA.
AC C3P2U9;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=HTH-type transcriptional regulator Hpr {ECO:0000255|HAMAP-Rule:MF_01911};
DE AltName: Full=Protease production regulatory protein Hpr {ECO:0000255|HAMAP-Rule:MF_01911};
GN Name=hpr {ECO:0000255|HAMAP-Rule:MF_01911}; OrderedLocusNames=BAA_1136;
OS Bacillus anthracis (strain A0248).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=592021;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A0248;
RA Dodson R.J., Munk A.C., Bruce D., Detter C., Tapia R., Sutton G., Sims D.,
RA Brettin T.;
RT "Genome sequence of Bacillus anthracis A0248.";
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of protease production and sporulation.
CC {ECO:0000255|HAMAP-Rule:MF_01911}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01911}.
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DR EMBL; CP001598; ACQ46235.1; -; Genomic_DNA.
DR RefSeq; WP_000834918.1; NC_012659.1.
DR AlphaFoldDB; C3P2U9; -.
DR SMR; C3P2U9; -.
DR GeneID; 59157265; -.
DR GeneID; 64200314; -.
DR KEGG; bai:BAA_1136; -.
DR HOGENOM; CLU_115790_0_0_9; -.
DR OMA; EKDWQNW; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01911; HTH_type_Hpr; 1.
DR InterPro; IPR000835; HTH_MarR-typ.
DR InterPro; IPR023488; HTH_tscrpt_reg_Hpr.
DR InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF01047; MarR; 1.
DR SMART; SM00347; HTH_MARR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS01117; HTH_MARR_1; 1.
DR PROSITE; PS50995; HTH_MARR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Repressor; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..185
FT /note="HTH-type transcriptional regulator Hpr"
FT /id="PRO_1000188789"
FT DOMAIN 13..157
FT /note="HTH marR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01911"
FT DNA_BIND 63..86
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01911"
SQ SEQUENCE 185 AA; 21733 MW; A5F01F355B557E89 CRC64;
MKSGEKDYSV KEAMIFSQRI AQLSKALWKC VEKDWQMWIK PYDLNINEHH ILTIAYHLKG
ASISEIAKFG VMHVSTAFNF SKKLEERGYL VFSKKEDDKR NTYIEITDKG EELLLRLMEE
YDPENNSVFN GALALRNFYG KFPENIELIA ILRNIYGQDF IDIFEKSLED IEENFTESDQ
KLVKK