HPR_BACAN
ID HPR_BACAN Reviewed; 185 AA.
AC Q81JG1; Q6I2D1; Q6KW58;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 141.
DE RecName: Full=HTH-type transcriptional regulator Hpr {ECO:0000255|HAMAP-Rule:MF_01911};
DE AltName: Full=Protease production regulatory protein Hpr {ECO:0000255|HAMAP-Rule:MF_01911};
GN Name=hpr {ECO:0000255|HAMAP-Rule:MF_01911};
GN OrderedLocusNames=BA_1045, GBAA_1045, BAS0976;
OS Bacillus anthracis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton;
RX PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT related bacteria.";
RL Nature 423:81-86(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RA Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA Richardson P., Rubin E., Tice H.;
RT "Complete genome sequence of Bacillus anthracis Sterne.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
CC -!- FUNCTION: Negative regulator of protease production and sporulation.
CC {ECO:0000255|HAMAP-Rule:MF_01911}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01911}.
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DR EMBL; AE016879; AAP25030.1; -; Genomic_DNA.
DR EMBL; AE017334; AAT30145.1; -; Genomic_DNA.
DR EMBL; AE017225; AAT53300.1; -; Genomic_DNA.
DR RefSeq; NP_843544.1; NC_003997.3.
DR RefSeq; WP_000834918.1; NZ_WXXJ01000044.1.
DR RefSeq; YP_027249.1; NC_005945.1.
DR AlphaFoldDB; Q81JG1; -.
DR SMR; Q81JG1; -.
DR IntAct; Q81JG1; 1.
DR STRING; 261594.GBAA_1045; -.
DR DNASU; 1088195; -.
DR EnsemblBacteria; AAP25030; AAP25030; BA_1045.
DR EnsemblBacteria; AAT30145; AAT30145; GBAA_1045.
DR GeneID; 59157265; -.
DR GeneID; 64200314; -.
DR KEGG; ban:BA_1045; -.
DR KEGG; bar:GBAA_1045; -.
DR KEGG; bat:BAS0976; -.
DR PATRIC; fig|198094.11.peg.1034; -.
DR eggNOG; COG1846; Bacteria.
DR HOGENOM; CLU_115790_0_0_9; -.
DR OMA; EKDWQNW; -.
DR Proteomes; UP000000427; Chromosome.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01911; HTH_type_Hpr; 1.
DR InterPro; IPR000835; HTH_MarR-typ.
DR InterPro; IPR023488; HTH_tscrpt_reg_Hpr.
DR InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF01047; MarR; 1.
DR SMART; SM00347; HTH_MARR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS01117; HTH_MARR_1; 1.
DR PROSITE; PS50995; HTH_MARR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..185
FT /note="HTH-type transcriptional regulator Hpr"
FT /id="PRO_0000343617"
FT DOMAIN 13..157
FT /note="HTH marR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01911"
FT DNA_BIND 63..86
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01911"
SQ SEQUENCE 185 AA; 21733 MW; A5F01F355B557E89 CRC64;
MKSGEKDYSV KEAMIFSQRI AQLSKALWKC VEKDWQMWIK PYDLNINEHH ILTIAYHLKG
ASISEIAKFG VMHVSTAFNF SKKLEERGYL VFSKKEDDKR NTYIEITDKG EELLLRLMEE
YDPENNSVFN GALALRNFYG KFPENIELIA ILRNIYGQDF IDIFEKSLED IEENFTESDQ
KLVKK