ID   HPR_BACLD               Reviewed;         206 AA.
AC   Q65LS8; Q62X69;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=HTH-type transcriptional regulator Hpr {ECO:0000255|HAMAP-Rule:MF_01911};
DE   AltName: Full=Protease production regulatory protein Hpr {ECO:0000255|HAMAP-Rule:MF_01911};
GN   Name=hpr {ECO:0000255|HAMAP-Rule:MF_01911};
GN   OrderedLocusNames=BLi01078, BL02906;
OS   Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS   NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=279010;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC   / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX   PubMed=15383718; DOI=10.1159/000079829;
RA   Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P.,
RA   Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.;
RT   "The complete genome sequence of Bacillus licheniformis DSM13, an organism
RT   with great industrial potential.";
RL   J. Mol. Microbiol. Biotechnol. 7:204-211(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC   / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX   PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA   Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA   Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA   Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A.,
RA   Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT   "Complete genome sequence of the industrial bacterium Bacillus
RT   licheniformis and comparisons with closely related Bacillus species.";
RL   Genome Biol. 5:R77.1-R77.12(2004).
CC   -!- FUNCTION: Negative regulator of protease production and sporulation.
CC       {ECO:0000255|HAMAP-Rule:MF_01911}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01911}.
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DR   EMBL; CP000002; AAU22639.1; -; Genomic_DNA.
DR   EMBL; AE017333; AAU39986.1; -; Genomic_DNA.
DR   RefSeq; WP_003180254.1; NC_006322.1.
DR   AlphaFoldDB; Q65LS8; -.
DR   SMR; Q65LS8; -.
DR   STRING; 279010.BL02906; -.
DR   EnsemblBacteria; AAU22639; AAU22639; BL02906.
DR   GeneID; 66216791; -.
DR   KEGG; bld:BLi01078; -.
DR   KEGG; bli:BL02906; -.
DR   eggNOG; COG1846; Bacteria.
DR   HOGENOM; CLU_115790_0_0_9; -.
DR   OMA; EKDWQNW; -.
DR   OrthoDB; 1744037at2; -.
DR   BioCyc; BLIC279010:BLI_RS05335-MON; -.
DR   Proteomes; UP000000606; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01911; HTH_type_Hpr; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023488; HTH_tscrpt_reg_Hpr.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Sporulation; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..206
FT                   /note="HTH-type transcriptional regulator Hpr"
FT                   /id="PRO_0000343624"
FT   DOMAIN          13..157
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01911"
FT   DNA_BIND        63..86
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01911"
FT   REGION          177..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   206 AA;  24129 MW;  792130E060FE4ED5 CRC64;
     MNRAEEPYTV KEALLFSQRM AQLSKALWKS IEKDWQQWIK PYDLNINEHH ILWIAYQLNG
     ASISEIAKFG VMHVSTAFNF SKKLEERGYL EFSKKLNDKR NTYIQLTPKG EEVFLKILES
     YDPTRNAVLK GAQPLHQLYG KFPEIVEMMS IIRHIYGDDF MEIFEKSFSN IENEFTSEEG
     KMKKKQEAKE AGESIEVDKP LEPLKN