ID   HPR_LYSSC               Reviewed;         186 AA.
AC   B1HVK6;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=HTH-type transcriptional regulator Hpr {ECO:0000255|HAMAP-Rule:MF_01911};
DE   AltName: Full=Protease production regulatory protein Hpr {ECO:0000255|HAMAP-Rule:MF_01911};
GN   Name=hpr {ECO:0000255|HAMAP-Rule:MF_01911}; OrderedLocusNames=Bsph_0398;
OS   Lysinibacillus sphaericus (strain C3-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX   NCBI_TaxID=444177;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C3-41;
RX   PubMed=18296527; DOI=10.1128/jb.01652-07;
RA   Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M.,
RA   Berry C., Yuan Z.;
RT   "Complete genome sequence of the mosquitocidal bacterium Bacillus
RT   sphaericus C3-41 and comparison with those of closely related Bacillus
RT   species.";
RL   J. Bacteriol. 190:2892-2902(2008).
CC   -!- FUNCTION: Negative regulator of protease production and sporulation.
CC       {ECO:0000255|HAMAP-Rule:MF_01911}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01911}.
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DR   EMBL; CP000817; ACA38025.1; -; Genomic_DNA.
DR   RefSeq; WP_008173331.1; NC_010382.1.
DR   AlphaFoldDB; B1HVK6; -.
DR   SMR; B1HVK6; -.
DR   EnsemblBacteria; ACA38025; ACA38025; Bsph_0398.
DR   GeneID; 29441251; -.
DR   KEGG; lsp:Bsph_0398; -.
DR   HOGENOM; CLU_115790_0_0_9; -.
DR   OMA; EKDWQNW; -.
DR   Proteomes; UP000002164; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01911; HTH_type_Hpr; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023488; HTH_tscrpt_reg_Hpr.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Sporulation; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..186
FT                   /note="HTH-type transcriptional regulator Hpr"
FT                   /id="PRO_0000343632"
FT   DOMAIN          13..157
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01911"
FT   DNA_BIND        63..86
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01911"
SQ   SEQUENCE   186 AA;  21957 MW;  487373D4BB9F7DA4 CRC64;
     MVLSEELYTQ KEAMLYSQRI AQLSKALWKA VEKDWQQWIK PYDLNINEHH ILWISYHLKG
     ASISDVAKFG VMHVSTAFNF SKKLEERGFL KFSKRDDDKR NTYVELTEAG TELIVEMNKN
     YHNTYHSVLE GSLALKDLYG RFPDFLDVMA VIRNIYGEDF IDIFERSFQH FRDSFDTLEE
     RPTVKG