ID   HPR_METMA               Reviewed;         123 AA.
AC   Q8Q0D6;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Putative hypoxanthine phosphoribosyltransferase;
DE            EC=2.-.-.-;
GN   OrderedLocusNames=MM_0201;
OS   Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM
OS   11833 / OCM 88) (Methanosarcina frisia).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=192952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88;
RX   PubMed=12125824;
RA   Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA   Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C.,
RA   Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S.,
RA   Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P.,
RA   Fritz H.-J., Gottschalk G.;
RT   "The genome of Methanosarcina mazei: evidence for lateral gene transfer
RT   between Bacteria and Archaea.";
RL   J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88;
RX   PubMed=21941461; DOI=10.1155/2011/439608;
RA   Ehlers C., Jager D., Schmitz R.A.;
RT   "Establishing a markerless genetic exchange system for Methanosarcina mazei
RT   strain Go1 for constructing chromosomal mutants of small RNA genes.";
RL   Archaea 2011:439608-439608(2011).
CC   -!- FUNCTION: May play a role in purine salvage.
CC   -!- DISRUPTION PHENOTYPE: Cells have increased resistance to the purine
CC       analog 8-aza-2,6-diaminopurine (8-ADP). {ECO:0000269|PubMed:21941461}.
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DR   EMBL; AE008384; AAM29897.1; -; Genomic_DNA.
DR   RefSeq; WP_011032155.1; NC_003901.1.
DR   AlphaFoldDB; Q8Q0D6; -.
DR   STRING; 192952.MM_0201; -.
DR   EnsemblBacteria; AAM29897; AAM29897; MM_0201.
DR   GeneID; 24882453; -.
DR   GeneID; 66135073; -.
DR   KEGG; mma:MM_0201; -.
DR   PATRIC; fig|192952.21.peg.243; -.
DR   eggNOG; arCOG05051; Archaea.
DR   HOGENOM; CLU_161126_0_0_2; -.
DR   OMA; FNIQATS; -.
DR   Proteomes; UP000000595; Chromosome.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
DR   InterPro; IPR019270; DUF2283.
DR   Pfam; PF10049; DUF2283; 1.
PE   4: Predicted;
KW   Purine salvage; Reference proteome; Transferase.
FT   CHAIN           1..123
FT                   /note="Putative hypoxanthine phosphoribosyltransferase"
FT                   /id="PRO_0000415444"
SQ   SEQUENCE   123 AA;  14177 MW;  E961E8CC99ADD040 CRC64;
     MRQESLVTKY DYDFENDSIF FYGSNKKYRS SIDLDGIILD IGEDDQIMAI EILDASNRFN
     LAKEDLRNIK YFEARIEVSE ENIRLTMKMS VNKRNKLVDK GLDALGLNSI NLPISTQGIE
     LNC