ID   HPS1_STAS1              Reviewed;         210 AA.
AC   Q49WT7;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=3-hexulose-6-phosphate synthase 1;
DE            Short=HPS 1;
DE            EC=4.1.2.43;
DE   AltName: Full=D-arabino-3-hexulose-6-phosphate formaldehyde lyase 1;
GN   OrderedLocusNames=SSP1619;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- FUNCTION: Catalyzes the condensation of ribulose 5-phosphate with
CC       formaldehyde to form 3-hexulose 6-phosphate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose
CC         6-phosphate; Xref=Rhea:RHEA:25201, ChEBI:CHEBI:16842,
CC         ChEBI:CHEBI:58121, ChEBI:CHEBI:58542; EC=4.1.2.43;
CC   -!- PATHWAY: One-carbon metabolism; formaldehyde assimilation via RuMP
CC       pathway; D-fructose 6-phosphate from D-ribulose 5-phosphate and
CC       formaldehyde: step 1/2.
CC   -!- SIMILARITY: Belongs to the HPS/KGPDC family. HPS subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AP008934; BAE18764.1; -; Genomic_DNA.
DR   RefSeq; WP_011303356.1; NZ_MTGA01000023.1.
DR   AlphaFoldDB; Q49WT7; -.
DR   SMR; Q49WT7; -.
DR   STRING; 342451.SSP1619; -.
DR   EnsemblBacteria; BAE18764; BAE18764; SSP1619.
DR   KEGG; ssp:SSP1619; -.
DR   PATRIC; fig|342451.11.peg.1618; -.
DR   eggNOG; COG0269; Bacteria.
DR   HOGENOM; CLU_081825_1_0_9; -.
DR   OMA; TTVAPHV; -.
DR   OrthoDB; 1625329at2; -.
DR   UniPathway; UPA00294; UER00434.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0043801; F:hexulose-6-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:InterPro.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0019647; P:formaldehyde assimilation via ribulose monophosphate cycle; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd04726; KGPDC_HPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR017553; 3-hexulose-6-phosphate_synth.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR041710; HPS/KGPDC.
DR   InterPro; IPR001754; OMPdeCOase_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   Pfam; PF00215; OMPdecase; 1.
DR   SMART; SM00934; OMPdecase; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   TIGRFAMs; TIGR03128; RuMP_HxlA; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Lyase; One-carbon metabolism; Reference proteome.
FT   CHAIN           1..210
FT                   /note="3-hexulose-6-phosphate synthase 1"
FT                   /id="PRO_0000269527"
SQ   SEQUENCE   210 AA;  22295 MW;  E3353A1EA078572F CRC64;
     MELQLAIDLL NKEEATILAN KVKDYINIVE IGTPIVINEG LPAVQHLNDN IDGVKVLADL
     KIMDAADYEV SQAVKFGADI VTILGVAEDA SIKAAVDEAH KHGKQLLVDM IAVQDLEKRA
     KDLDDLGADY IAVHTGYDLQ AEGQSPLESL RKVKSVISNS KVAVAGGIKP DTIKDIVAEN
     PDLIIVGGGI ANADDPVEAA KQCRAAIEGK