ID   HPS4_PITAZ              Reviewed;          12 AA.
AC   P84956;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   29-SEP-2021, entry version 17.
DE   RecName: Full=Hyposin-H4 {ECO:0000303|PubMed:18644413};
DE            Short=HPS-H4 {ECO:0000303|PubMed:18644413};
DE   AltName: Full=Hyposin-3 {ECO:0000303|PubMed:18644413};
DE   AltName: Full=Hyposin-HA3 {ECO:0000303|PubMed:17696382};
OS   Pithecopus azureus (Orange-legged monkey tree frog) (Phyllomedusa azurea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=2034991;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND AMIDATION AT LYS-12.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:17696382};
RX   PubMed=17696382; DOI=10.1021/pr0702666;
RA   Thompson A.H., Bjourson A.J., Orr D.F., Shaw C., McClean S.;
RT   "Amphibian skin secretomics: application of parallel quadrupole time-of-
RT   flight mass spectrometry and peptide precursor cDNA cloning to rapidly
RT   characterize the skin secretory peptidome of Phyllomedusa hypochondrialis
RT   azurea: discovery of a novel peptide family, the hyposins.";
RL   J. Proteome Res. 6:3604-3613(2007).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18644413; DOI=10.1016/j.peptides.2008.06.017;
RA   Amiche M., Ladram A., Nicolas P.;
RT   "A consistent nomenclature of antimicrobial peptides isolated from frogs of
RT   the subfamily Phyllomedusinae.";
RL   Peptides 29:2074-2082(2008).
CC   -!- FUNCTION: Has antimicrobial activity. {ECO:0000250|UniProtKB:P84524}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17696382}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:17696382}.
CC   -!- MASS SPECTROMETRY: Mass=1335.87; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:17696382};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Hyposin subfamily. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=00905";
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..12
FT                   /note="Hyposin-H4"
FT                   /evidence="ECO:0000269|PubMed:17696382"
FT                   /id="PRO_0000250431"
FT   MOD_RES         12
FT                   /note="Lysine amide"
FT                   /evidence="ECO:0000269|PubMed:17696382"
SQ   SEQUENCE   12 AA;  1338 MW;  DD7824E5C812C042 CRC64;
     LRPAVIVRTK GK