ID   HPS5_AEDAE              Reviewed;         845 AA.
AC   Q177G4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=BLOC-2 complex member HPS5 homolog {ECO:0000305};
DE   AltName: Full=Hermansky-Pudlak syndrome 5 protein homolog;
DE   AltName: Full=Protein pink;
GN   Name=p {ECO:0000250|UniProtKB:Q9VHN9}; ORFNames=AAEL006142;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1] {ECO:0000312|EMBL:EAT42313.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Has a role in the biogenesis of eye pigment granules. Eye
CC       pigment granules are specialized forms of late endosomes or lysosomes.
CC       Biogenesis of pigment granules in the eye requires molecular components
CC       required for protein delivery to lysosomes (By similarity).
CC       {ECO:0000250|UniProtKB:Q9VHN9}.
CC   -!- SIMILARITY: Belongs to the HPS5 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH477376; EAT42313.1; -; Genomic_DNA.
DR   RefSeq; XP_001657527.1; XM_001657477.1.
DR   AlphaFoldDB; Q177G4; -.
DR   STRING; 7159.AAEL006142-PA; -.
DR   GeneID; 5567532; -.
DR   KEGG; aag:5567532; -.
DR   VEuPathDB; VectorBase:AAEL006142; -.
DR   eggNOG; KOG3621; Eukaryota.
DR   HOGENOM; CLU_302332_0_0_1; -.
DR   InParanoid; Q177G4; -.
DR   OMA; QPSRIYC; -.
DR   OrthoDB; 416267at2759; -.
DR   PhylomeDB; Q177G4; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0031409; F:pigment binding; IEA:UniProtKB-KW.
DR   GO; GO:0006726; P:eye pigment biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0006622; P:protein targeting to lysosome; ISS:UniProtKB.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR035431; HPS5.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PIRSF; PIRSF037475; BLOC-2_complex_Hps5; 1.
PE   3: Inferred from homology;
KW   Pigment; Reference proteome; Sensory transduction; Vision.
FT   CHAIN           1..845
FT                   /note="BLOC-2 complex member HPS5 homolog"
FT                   /id="PRO_0000302854"
FT   REGION          239..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        241..258
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   845 AA;  96521 MW;  EFFDCC8DF660ADDD CRC64;
     MIMDALRHYG LSQQRTELTS AIQLPLRNTR RIKFTCFDVS EKYIIFGANS GSLYVYDRES
     VNFLSIIPSQ LGTISQVQIS SNGKQIAVAN MRGAIGVVLD LDGSASKEVL LTELGGGEAA
     GGVGVVGRSG TTAFVTSFCW GEDDKELYCG DSKGTVSLLQ LSMFMGRNIL NMTLSPVLLL
     ENHIVQIDRY KELLLVSTLS KCVLCNTQRE EFKQIGNRPR DGLYGATFIV PNPEYFNTPT
     EEDLEDAKSM EGSDDNDNDQ RSSPSGVKIA QDQVRIFCSR PGSRLWEADI DGNVLRTHQF
     RHRSTDREAN GPCNEIIAFK LLQKVLGRLI LVHDDREIFL IDPIASQVVL WINNVGDISR
     VRLVGEDIYV FGNDQTMMKL RLDVEQKEVP KRLPKKINGK KSSPFKENGV YILDHLFNNN
     GLKEGTLQTE STIKEALASV VRGKYGRNIK QMFLGYDQMG PERPKTLNIS KVYNSEESYN
     NMVQVLPTDE SSYAEDDCSE DVVPKRNPPK KMFSMSLLSD YQLSEDDKTV RNLYLVYRSS
     IISNLNFADR YAKIFDAYDT ESIVSLLHKL EIVMDENNEE QSRLKCIKIY FDYLKVELIW
     EIDVESRAFI KQCFIEYNKM LLHEELCELE KCESCGHYLR TNINCHYPEI GTTLIQYYWS
     RKDYAHCFEL VQQIPFLWHT ITKFYIQDNR EDKAIQCIWN VGDPGLLERA ACEMFTMDHW
     RQLLDLMLTC YNSNSLMCLN CDKLCTLADP GRNPMWREQQ NQAQSPVVNP KDNNHINNNN
     IGITTRGSTN VNRFYSWNYI LNTAIDQKCV DGKSMLKLLR GYDEYIPKGA ISTSFYLKCL
     LNVSD