ID   HPS5_ANOGA              Reviewed;         830 AA.
AC   Q5TU55;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=BLOC-2 complex member HPS5 homolog {ECO:0000305};
DE   AltName: Full=Hermansky-Pudlak syndrome 5 protein homolog;
DE   AltName: Full=Protein pink;
GN   Name=p {ECO:0000250|UniProtKB:Q9VHN9};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Has a role in the biogenesis of eye pigment granules. Eye
CC       pigment granules are specialized forms of late endosomes or lysosomes.
CC       Biogenesis of pigment granules in the eye requires molecular components
CC       required for protein delivery to lysosomes (By similarity).
CC       {ECO:0000250|UniProtKB:Q9VHN9}.
CC   -!- SIMILARITY: Belongs to the HPS5 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAAB01008859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q5TU55; -.
DR   SMR; Q5TU55; -.
DR   STRING; 7165.AGAP013499-PA; -.
DR   VEuPathDB; VectorBase:AGAP013499; -.
DR   eggNOG; KOG3621; Eukaryota.
DR   HOGENOM; CLU_302332_0_0_1; -.
DR   InParanoid; Q5TU55; -.
DR   Proteomes; UP000007062; Chromosome 2R.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0031409; F:pigment binding; IEA:UniProtKB-KW.
DR   GO; GO:0048066; P:developmental pigmentation; IBA:GO_Central.
DR   GO; GO:0006726; P:eye pigment biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0006622; P:protein targeting to lysosome; ISS:UniProtKB.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR035431; HPS5.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PIRSF; PIRSF037475; BLOC-2_complex_Hps5; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Pigment; Reference proteome; Repeat; Sensory transduction;
KW   Vision; WD repeat.
FT   CHAIN           1..830
FT                   /note="BLOC-2 complex member HPS5 homolog"
FT                   /id="PRO_0000302763"
FT   REPEAT          25..64
FT                   /note="WD 1"
FT   REPEAT          67..106
FT                   /note="WD 2"
FT   REPEAT          114..153
FT                   /note="WD 3"
FT   COILED          578..604
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   830 AA;  94372 MW;  1D565CAE1AD21177 CRC64;
     MDATNKQYAL RDRAELSAFV NQPFRNNSRI KFTCFDCSPK YFVFGANSGS LYLYDRITTS
     FLAIFPSQLG TIGKVSISHN EKQIAIGNQT GSIGILSTEL APSTDGEGQP IDLGGPAFVT
     SFCWTEDDRE LYCGDSRGIV SLIQFSLFMG RNILNISLHP VLLLENRIVQ IDRYKDLLLV
     STLSKCVLCN TAREEFKQIG NRPRDGHATT TTTTPSPPLM IVDEEDVRIF CSRPGSRLWE
     ADLEGNVIRT HQFKQAAAAA AAQQQLQCLQ ESELATAPTE APDGTLMVVP FQVLYSIRRQ
     LLLVHDRCQL LIIDPLHSKI VLRTDEFTDI THVAVVDEWI YLLTGENRVF QVRVEIQGDE
     DPFPTPGMVD EPCLESRKQK QGVYILDSML NNNNNNNGKQ MNGKESPLLL STEATIKEAL
     VSVVRGKYGR NIKQMFMGYE QQQQQRTPSG APERPKTLNL TKIYEPSRSN AFANGNGHAL
     LAEFGIEAEV EDLECDDMME ELVQTRTGQA LLGTAMPNGA GTGKQQPGKK KFSTSLLDGY
     ETSEDDATVR NLYLIFRSSI ISNLNFADRY AKIFDEYDTE TIVRLLRKLE TLMEENEEPN
     ARLKCMRIYF HYLKPELLWE IDADSRQFIK DGFIVCNTTD GADRARLERL AHCAACGYYL
     EATASCHYRE IGTSLLQYYW SRKEYDECFA MVKRVPYLWR TITRYYIQDR REDKVVQCVW
     NLADSELLER AAGELPFELD HWRQLFELAI AYHQRHEMIC LSCDKPTGGR LEDNQPESQF
     RQWNYLLGVA LAHIRSPTEL LCLVRRYADN IPRGAIAPSF YIRCLLLEAK