ID   HPS5_DROPS              Reviewed;         830 AA.
AC   Q297N8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=BLOC-2 complex member HPS5 homolog {ECO:0000305};
DE   AltName: Full=Hermansky-Pudlak syndrome 5 protein homolog;
DE   AltName: Full=Protein pink;
GN   Name=p {ECO:0000250|UniProtKB:Q9VHN9}; ORFNames=GA22022;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1] {ECO:0000312|EMBL:EAL28167.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Has a role in the biogenesis of eye pigment granules. Eye
CC       pigment granules are specialized forms of late endosomes or lysosomes.
CC       Biogenesis of pigment granules in the eye requires molecular components
CC       required for protein delivery to lysosomes (By similarity).
CC       {ECO:0000250|UniProtKB:Q9VHN9}.
CC   -!- SIMILARITY: Belongs to the HPS5 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL28167.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CM000070; EAL28167.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001359024.1; XM_001358987.3.
DR   AlphaFoldDB; Q297N8; -.
DR   SMR; Q297N8; -.
DR   STRING; 7237.FBpp0284155; -.
DR   EnsemblMetazoa; FBtr0285717; FBpp0284155; FBgn0082007.
DR   KEGG; dpo:Dpse_GA22022; -.
DR   eggNOG; KOG3621; Eukaryota.
DR   HOGENOM; CLU_302332_0_0_1; -.
DR   InParanoid; Q297N8; -.
DR   OMA; QPSRIYC; -.
DR   PhylomeDB; Q297N8; -.
DR   ChiTaRS; p; fly.
DR   Proteomes; UP000001819; Genome assembly.
DR   Bgee; FBgn0082007; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblMetazoa.
DR   GO; GO:0031409; F:pigment binding; IEA:UniProtKB-KW.
DR   GO; GO:0048072; P:compound eye pigmentation; IEA:EnsemblMetazoa.
DR   GO; GO:0006726; P:eye pigment biosynthetic process; ISS:UniProtKB.
DR   GO; GO:1900369; P:negative regulation of post-transcriptional gene silencing by RNA; IEA:EnsemblMetazoa.
DR   GO; GO:0006727; P:ommochrome biosynthetic process; IEA:EnsemblMetazoa.
DR   GO; GO:0006622; P:protein targeting to lysosome; ISS:UniProtKB.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR035431; HPS5.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PIRSF; PIRSF037475; BLOC-2_complex_Hps5; 1.
PE   3: Inferred from homology;
KW   Pigment; Reference proteome; Repeat; Sensory transduction; Vision;
KW   WD repeat.
FT   CHAIN           1..830
FT                   /note="BLOC-2 complex member HPS5 homolog"
FT                   /id="PRO_0000302765"
FT   REPEAT          62..101
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          109..148
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   830 AA;  94782 MW;  0B11E5C2DF976BAF CRC64;
     MADEYCLTNF IDFSLSLSLP LKHNRIKYTC FDISDSYIIF GASSGSLYLF NRNGKFLHLI
     PNKHGAITNL SISANNKYVA FSTQRSLICV YVVNLSAQAT PQVIVTHLDQ SVQVSCIHWT
     QDEKQFYYGD SRGQVNLVLL SSFIGHSLLL NMTVHPLLYL DSPIVQIDDF ESLLLVSNCT
     KCILCNTEYE EYKQIGNRPR DGAYGACFFI SPHESVQPSR IYCARPGTRI WEVDFEGEVI
     QTHQFKTALA TAPAKIQKTT NVDNNADELD SNDELLDYQP QQLQFSRVQR LSHDFLLAYT
     ELGLYIFDVR NSSVVLWCNQ FERILDCRVS GMEIFVFTQT GSLYSVQLQT LHGYSITLMH
     QSKLLQCANL LRQHVKYFAD KARENYELKL LNQLKQLLIE RQEYELLNDI SVIFDAIAQC
     TGTALDTQSS GGSSAATERS GSMRAIGVST TKGPPKGVYV LENAFCDNLK QQPKSGHFKD
     ALLTVTGKFG KNIIKYKFNI FAEEQQQLVR ELIPASERSL PFKDIKARYE SGDVGEEEIV
     SRCKRPTPQA PHISPEEKTI YNLYLICKSA KFSRTHCVER YRAVFDEYAA SELIALMGKL
     AQLMVEHGDG QEQAERNCYE MYFNYLNPEL IWEVDDSTRD YIASGFVLLN APQCMEIVRC
     DHCAFPLRFD NACQYHELGA VLLRYFWSRN EQLKCFDVVQ AVPALLDVLA KFYLAEQNLD
     KVIPIVLNYG QPELLLDVGR QLNVSAWARC FEQFAELQRG RLICVNCECV SSVEQDQLTR
     HFFYTWNCFL NIALDHLTAS DTLSLIFKWS SYIPNDAIDR EFYSRCLIKG