ID   3SX1_MICCK              Reviewed;          66 AA.
AC   C0HK04;
DT   06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
DT   06-JUL-2016, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Clarkitoxin-1 {ECO:0000305|PubMed:27164141};
DE   AltName: Full=Clarkitoxin-I {ECO:0000303|PubMed:27164141};
DE   AltName: Full=Three-finger toxin;
DE            Short=3FTx;
OS   Micrurus clarki (Clark's coral snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Micrurus.
OX   NCBI_TaxID=1817999 {ECO:0000303|PubMed:27164141};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Venom {ECO:0000303|PubMed:27164141};
RX   PubMed=27164141; DOI=10.3390/toxins8050138;
RA   Lomonte B., Sasa M., Rey-Suarez P., Bryan W., Gutierrez J.M.;
RT   "Venom of the Coral Snake Micrurus clarki: Proteomic Profile, Toxicity,
RT   Immunological Cross-Neutralization, and Characterization of a Three-Finger
RT   Toxin.";
RL   Toxins 8:0-0(2016).
CC   -!- FUNCTION: Not toxic to mice when injected intravenously or
CC       intraperitoneally. {ECO:0000269|PubMed:27164141}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27164141}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:27164141}.
CC   -!- MASS SPECTROMETRY: Mass=7537; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:27164141};
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; C0HK04; -.
DR   SMR; C0HK04; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   Pfam; PF00021; UPAR_LY6; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted.
FT   PEPTIDE         1..66
FT                   /note="Clarkitoxin-1"
FT                   /evidence="ECO:0000269|PubMed:27164141"
FT                   /id="PRO_0000436847"
FT   DISULFID        3..24
FT                   /evidence="ECO:0000250|UniProtKB:P0DKS3"
FT   DISULFID        17..42
FT                   /evidence="ECO:0000250|UniProtKB:P0DKS3"
FT   DISULFID        46..59
FT                   /evidence="ECO:0000250|UniProtKB:P0DKS3"
FT   DISULFID        60..65
FT                   /evidence="ECO:0000250|UniProtKB:P0DKS3"
FT   UNSURE          63..66
FT                   /evidence="ECO:0000303|PubMed:27164141"
SQ   SEQUENCE   66 AA;  7543 MW;  C07032985DB58E66 CRC64;
     RICDDSSIPF LRTPQLCPKG QDVCYKKTPI VKKFKWLQKK GCASSCPKNG FIKIFKIECC
     TKDNCI