ID   HPS6_PITHY              Reviewed;          14 AA.
AC   P86921;
DT   28-MAR-2018, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Hyposin-H6 {ECO:0000305};
DE            Short=HPS-H6 {ECO:0000305};
DE   AltName: Full=Hyposin HA-6 {ECO:0000303|PubMed:23029273};
OS   Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa
OS   hypochondrialis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=317381 {ECO:0000303|PubMed:23029273};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND AMIDATION AT
RP   LEU-14.
RC   TISSUE=Skin secretion {ECO:0000303|Ref.1};
RA   Silva L.R., Bloch C. Jr.;
RL   Submitted (MAY-2011) to UniProtKB.
RN   [2] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=23029273; DOI=10.1371/journal.pone.0045848;
RA   Brand G.D., Magalhaes M.T., Tinoco M.L., Aragao F.J., Nicoli J.,
RA   Kelly S.M., Cooper A., Bloch C. Jr.;
RT   "Probing protein sequences as sources for encrypted antimicrobial
RT   peptides.";
RL   PLoS ONE 7:E45848-E45848(2012).
CC   -!- FUNCTION: Antibacterial peptide active against X.axonopodis pv.
CC       glycines (MIC=42 uM). Not active against E.coli ATCC 25922, S.aureus
CC       ATCC 29313 or P.aeruginosa ATCC 27853. {ECO:0000269|PubMed:23029273}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands. {ECO:0000305|Ref.1}.
CC   -!- MASS SPECTROMETRY: Mass=1519.05; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Hyposin subfamily. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Secreted.
FT   PEPTIDE         1..14
FT                   /note="Hyposin-H6"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000443549"
FT   MOD_RES         14
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   14 AA;  1520 MW;  D70E0E7824E6A812 CRC64;
     LRPAILVRVK GKGL