ID   HPS_METBF               Reviewed;         413 AA.
AC   Q46DA4;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=3-hexulose-6-phosphate synthase;
DE            Short=HPS;
DE            EC=4.1.2.43;
DE   AltName: Full=D-arabino-3-hexulose-6-phosphate formaldehyde lyase;
GN   Name=hpsA; OrderedLocusNames=Mbar_A1170;
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fusaro / DSM 804;
RX   PubMed=16980466; DOI=10.1128/jb.00810-06;
RA   Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S.,
RA   Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.;
RT   "The Methanosarcina barkeri genome: comparative analysis with
RT   Methanosarcina acetivorans and Methanosarcina mazei reveals extensive
RT   rearrangement within methanosarcinal genomes.";
RL   J. Bacteriol. 188:7922-7931(2006).
CC   -!- FUNCTION: Catalyzes the condensation of ribulose 5-phosphate with
CC       formaldehyde to form 3-hexulose 6-phosphate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose
CC         6-phosphate; Xref=Rhea:RHEA:25201, ChEBI:CHEBI:16842,
CC         ChEBI:CHEBI:58121, ChEBI:CHEBI:58542; EC=4.1.2.43;
CC   -!- SIMILARITY: Belongs to the HPS/KGPDC family. HPS subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CP000099; AAZ70138.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q46DA4; -.
DR   SMR; Q46DA4; -.
DR   STRING; 269797.Mbar_A1170; -.
DR   EnsemblBacteria; AAZ70138; AAZ70138; Mbar_A1170.
DR   KEGG; mba:Mbar_A1170; -.
DR   eggNOG; arCOG00053; Archaea.
DR   HOGENOM; CLU_637161_0_0_2; -.
DR   OMA; NISDAMH; -.
DR   GO; GO:0043801; F:hexulose-6-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:InterPro.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd04726; KGPDC_HPS; 1.
DR   CDD; cd16841; RraA_family; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017120; Bifunct_HPS/DMK_prd.
DR   InterPro; IPR041710; HPS/KGPDC.
DR   InterPro; IPR001754; OMPdeCOase_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   InterPro; IPR005493; RraA/RraA-like.
DR   InterPro; IPR036704; RraA/RraA-like_sf.
DR   Pfam; PF00215; OMPdecase; 1.
DR   Pfam; PF03737; RraA-like; 1.
DR   PIRSF; PIRSF037137; HPS_DMK_prd; 1.
DR   SMART; SM00934; OMPdecase; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   SUPFAM; SSF89562; SSF89562; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Lyase.
FT   CHAIN           1..413
FT                   /note="3-hexulose-6-phosphate synthase"
FT                   /id="PRO_0000235170"
SQ   SEQUENCE   413 AA;  44174 MW;  1405BBBC884F4F7C CRC64;
     MDRAVEIAKE AIAGGADWIE IGTPLIKSEG MDAIRTMRKA FPDRTILADM KTVDTGAIEV
     EMAAKAGADV VIVLGSADDS TLLDALRSSH KYGVRLMADL ISAPDPVKRV VELEALGVDY
     VNVHIGIDQQ MMGKDPIALL REISQRVNVQ LAVAGGLDAN SAVQAVKAGA KVVIVGGNIT
     HSDNVTEAAR KIRQSVDSPD AVEICSVSTV DQEIREILKE VSTSNISDAM HRKGAMKGIH
     PLVRGKMVGT AVTVQTFPGD WAKPVEAIDI AKEGDVIVIY NENKDVACWG GLATWSALNK
     GIAGLVIEGA VRDIDEVETL GLPIYTSNTV PNAGDPKGFG EINAEITCGG QAVKPGDYIV
     GDESGVVVIP AERAYELARR AKEVYKTEKR LFDEIKRGGT LSEIMDLKKW EKH