HPS_STAEQ
ID HPS_STAEQ Reviewed; 210 AA.
AC Q5HRH7;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=3-hexulose-6-phosphate synthase;
DE Short=HPS;
DE EC=4.1.2.43;
DE AltName: Full=D-arabino-3-hexulose-6-phosphate formaldehyde lyase;
GN OrderedLocusNames=SERP0216;
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- FUNCTION: Catalyzes the condensation of ribulose 5-phosphate with
CC formaldehyde to form 3-hexulose 6-phosphate. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose
CC 6-phosphate; Xref=Rhea:RHEA:25201, ChEBI:CHEBI:16842,
CC ChEBI:CHEBI:58121, ChEBI:CHEBI:58542; EC=4.1.2.43;
CC -!- PATHWAY: One-carbon metabolism; formaldehyde assimilation via RuMP
CC pathway; D-fructose 6-phosphate from D-ribulose 5-phosphate and
CC formaldehyde: step 1/2.
CC -!- SIMILARITY: Belongs to the HPS/KGPDC family. HPS subfamily.
CC {ECO:0000305}.
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DR EMBL; CP000029; AAW53588.1; -; Genomic_DNA.
DR RefSeq; WP_001832167.1; NC_002976.3.
DR AlphaFoldDB; Q5HRH7; -.
DR SMR; Q5HRH7; -.
DR STRING; 176279.SERP0216; -.
DR EnsemblBacteria; AAW53588; AAW53588; SERP0216.
DR GeneID; 50019496; -.
DR KEGG; ser:SERP0216; -.
DR eggNOG; COG0269; Bacteria.
DR HOGENOM; CLU_081825_1_0_9; -.
DR OMA; TTVAPHV; -.
DR OrthoDB; 1625329at2; -.
DR UniPathway; UPA00294; UER00434.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0043801; F:hexulose-6-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0019647; P:formaldehyde assimilation via ribulose monophosphate cycle; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR CDD; cd04726; KGPDC_HPS; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR InterPro; IPR017553; 3-hexulose-6-phosphate_synth.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR041710; HPS/KGPDC.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR Pfam; PF00215; OMPdecase; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
DR TIGRFAMs; TIGR03128; RuMP_HxlA; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Lyase; One-carbon metabolism; Reference proteome.
FT CHAIN 1..210
FT /note="3-hexulose-6-phosphate synthase"
FT /id="PRO_0000269524"
SQ SEQUENCE 210 AA; 22344 MW; E295DA62AAFF1142 CRC64;
MELQLAIDLL NKEEAAKLAQ KVEEYVDIVE IGTPIVINEG LPAVQHLNEN INNAKVLADL
KIMDAADYEV SQAVKYGADI VTILGVAEDA SIKAAVEEAH KHGKALLVDM IAVQNLEQRA
KELDEMGADY IAVHTGYDLQ AEGKSPLDSL RTVKSVIKNS KVAVAGGIKP DTIKDIVAED
PDLVIVGGGI ANADDPVEAA KQCRAAIEGK
