HPT1_ORYSJ
ID HPT1_ORYSJ Reviewed; 404 AA.
AC B7FA90; A0A0N7KMJ1; Q0DAE9; Q67U28;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Probable homogentisate phytyltransferase 1, chloroplastic;
DE EC=2.5.1.115;
DE AltName: Full=Vitamin E pathway gene 2-1 protein;
DE Short=OsVTE2-1;
DE Flags: Precursor;
GN Name=HPT1; Synonyms=VTE2-1; OrderedLocusNames=Os06g0658900, LOC_Os06g44840;
GN ORFNames=B1047G05.17, P0677B10.32;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RG The rice full-length cDNA consortium;
RT "Oryza sativa full length cDNA.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NOMENCLATURE.
RX PubMed=16408209; DOI=10.1007/s00425-005-0180-1;
RA Venkatesh T.V., Karunanandaa B., Free D.L., Rottnek J.M., Baszis S.R.,
RA Valentin H.E.;
RT "Identification and characterization of an Arabidopsis homogentisate
RT phytyltransferase paralog.";
RL Planta 223:1134-1144(2006).
CC -!- FUNCTION: Involved in the synthesis of tocopherol (vitamin E).
CC Catalyzes the condensation of homogentisate and phytyl diphosphate to
CC form dimethylphytylhydroquinone (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + homogentisate + phytyl diphosphate = 2-methyl-6-phytyl-
CC 1,4-benzene-1,4-diol + CO2 + diphosphate; Xref=Rhea:RHEA:37975,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16169, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:75434, ChEBI:CHEBI:75920;
CC EC=2.5.1.115;
CC -!- PATHWAY: Cofactor biosynthesis; tocopherol biosynthesis.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD37835.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAD38343.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAF20174.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP004803; BAD37835.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP005760; BAD38343.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008212; BAF20174.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014962; BAS98961.1; -; Genomic_DNA.
DR EMBL; AK243323; BAH01538.1; -; mRNA.
DR RefSeq; XP_015644510.1; XM_015789024.1.
DR RefSeq; XP_015644511.1; XM_015789025.1.
DR AlphaFoldDB; B7FA90; -.
DR STRING; 4530.OS06T0658900-01; -.
DR PaxDb; B7FA90; -.
DR PRIDE; B7FA90; -.
DR EnsemblPlants; Os06t0658900-01; Os06t0658900-01; Os06g0658900.
DR GeneID; 4341727; -.
DR Gramene; Os06t0658900-01; Os06t0658900-01; Os06g0658900.
DR KEGG; osa:4341727; -.
DR eggNOG; ENOG502R0I3; Eukaryota.
DR HOGENOM; CLU_048963_0_0_1; -.
DR InParanoid; B7FA90; -.
DR OMA; FYQFIWK; -.
DR OrthoDB; 1231215at2759; -.
DR PlantReactome; R-OSA-1119287; Vitamin E biosynthesis.
DR UniPathway; UPA00160; -.
DR Proteomes; UP000000763; Chromosome 6.
DR Proteomes; UP000059680; Chromosome 6.
DR Genevisible; B7FA90; OS.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0010176; F:homogentisate phytyltransferase activity; IEA:RHEA.
DR GO; GO:0010189; P:vitamin E biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd13960; PT_UbiA_HPT1; 1.
DR Gene3D; 1.10.357.140; -; 1.
DR InterPro; IPR044502; AtHST-like.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR InterPro; IPR044878; UbiA_sf.
DR Pfam; PF01040; UbiA; 1.
PE 2: Evidence at transcript level;
KW Chloroplast; Membrane; Plastid; Reference proteome; Thylakoid; Transferase;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..77
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 78..404
FT /note="Probable homogentisate phytyltransferase 1,
FT chloroplastic"
FT /id="PRO_0000409870"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 68..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 404 AA; 44501 MW; 65B7E822C583A326 CRC64;
MDSLRLRPSL LAARAPGAAS LPPLRRDHFL PPLCSIHRNG KRPVSLSSQR TQGPSFDQCQ
KFFGWKSSHH RIPHRPTSSS ADASGQPLQS SAEAHDSSSI WKPISSSLDA FYRFSRPHTV
IGTALSIVSV SLLAVENLSD VSPLFLTGLL EAVVAALFMN IYIVGLNQLF DIEIDKVNKP
TLPLASGEYS PATGVALVSA FAAMSFGLGW AVGSQPLFLA LFISFILGTA YSINLPFLRW
KRSAVVAALC ILAVRAVIVQ LAFFLHIQTF VFRRPAVFTR PLIFATAFMT FFSVVIALFK
DIPDIEGDRI FGIKSFSVRL GQKKVFWICV GLLEMAYCVA ILMGATSACL WSKYATVVGH
AILAAILWNR SRSIDLTSKT AITSFYMFIW KLFYAEYLLI PLVR
