ID   HPUB_NEIMA              Reviewed;         810 AA.
AC   Q9JWA2; A1IPT4;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Hemoglobin-haptoglobin utilization protein B;
DE   Flags: Precursor;
GN   Name=hpuB; OrderedLocusNames=NMA0474;
OS   Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 /
OS   Z2491).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15465 / Z2491;
RX   PubMed=10761919; DOI=10.1038/35006655;
RA   Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M.,
RA   Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M.,
RA   Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA   Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G.,
RA   Barrell B.G.;
RT   "Complete DNA sequence of a serogroup A strain of Neisseria meningitidis
RT   Z2491.";
RL   Nature 404:502-506(2000).
CC   -!- FUNCTION: Acts as a receptor for hemoglobin or the
CC       hemoglobin/haptoglobin complex and is required for heme uptake.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Peripheral
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AL157959; CAM07755.1; -; Genomic_DNA.
DR   PIR; A81965; A81965.
DR   RefSeq; WP_010981084.1; NC_003116.1.
DR   AlphaFoldDB; Q9JWA2; -.
DR   SMR; Q9JWA2; -.
DR   PRIDE; Q9JWA2; -.
DR   EnsemblBacteria; CAM07755; CAM07755; NMA0474.
DR   KEGG; nma:NMA0474; -.
DR   HOGENOM; CLU_008287_19_0_4; -.
DR   OMA; QYARGFR; -.
DR   BioCyc; NMEN122587:NMA_RS02405-MON; -.
DR   Proteomes; UP000000626; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProt.
DR   GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Receptor; Signal; TonB box; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..810
FT                   /note="Hemoglobin-haptoglobin utilization protein B"
FT                   /id="PRO_0000034760"
FT   MOTIF           793..810
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   810 AA;  90571 MW;  D38DE1DCA3CA5A6E CRC64;
     MPIPFKPVLA AAAIAQAFPA FAADPAPQSA QTLNEITVTG THKTQKLGEE KIRRKTLDKL
     LVNDEHDLVR YDPGISVVEG GRAGSNGFTI RGVDKDRVAI NVDGLAQAES RSSEAFQELF
     GAYGNFNANR NTSEPENFSE VTITKGADSL KSGSGALGGA VNYQTKSASD YVSEDKPYHL
     GIKGGSVGKN SQKFSSITAA GRLFGLDALL VYTRRFGKET KNRSTEGDIE IKNDGYVYNP
     TDTGGPSKYL TYVATGVARS QPDPQEWVNK STLFKLGYNF NDQNRIGWIF EDSRTDRFTN
     ELSNLWTGTT TSAATGDYRH RQDVSYRRRS GVEYKNELEH GPWDSLKLRY DKQRIDMNTW
     TWDIPKNYDK RGINGEVYHS FRHIRQNTAQ WTADFEKQLD FSKAVWAAQY GLGGGKGDNA
     NSDYSYFAKL YDPKILASNQ AKITMLIENR SKYKFAYWNN AFHLGGNDRF RLNAGIRYDK
     NSSSAKDDPK YTTAIRGQIP HLGSERAHAG FSYGTGFDWR FTKHLHLLAK YSTGFRAPTS
     DETWLLFPHP DFYLKANPNL KAEKAKNWEL GLAGSGKAGN FKLSGFKTKY RDFIELTYMG
     VSSDDKNNPR YAPLSDGTAL VSSPVWQNQN RSAAWVKGIE FNGTWNLDSI GLPKGLHTGL
     NVSYIKGKAT QNNGKETPIN ALSPWTAVYS LGYDAPSKRW GINAYATRTA AKKPSDTVHS
     NDDLNNPWPY AKHSKAYTLF DLSAYLNIGK QVTLRAAAYN ITNKQYYTWE SLRSIREFGT
     VNRVDNKTHA GIQRFTSPGR SYNFTIEAKF