ID   HPUB_NEIMC              Reviewed;         810 AA.
AC   P96949;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Hemoglobin-haptoglobin utilization protein B;
DE   Flags: Precursor;
GN   Name=hpuB;
OS   Neisseria meningitidis serogroup C.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=135720;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DNM2 / Serogroup C / Serotype 2a;
RX   PubMed=9157245; DOI=10.1046/j.1365-2958.1997.2501619.x;
RA   Lewis L.A., Gray E., Wang Y.-P., Roe B.A., Dyer D.W.;
RT   "Molecular characterization of hpuAB, the haemoglobin-haptoglobin-
RT   utilization operon of Neisseria meningitidis.";
RL   Mol. Microbiol. 23:737-749(1997).
CC   -!- FUNCTION: Acts as a receptor for hemoglobin or the
CC       hemoglobin/haptoglobin complex and is required for heme uptake.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Peripheral
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; U73112; AAC44893.2; -; Genomic_DNA.
DR   AlphaFoldDB; P96949; -.
DR   SMR; P96949; -.
DR   TCDB; 1.B.14.2.3; the outer membrane receptor (omr) family.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProt.
DR   GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Receptor; Signal; TonB box; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..810
FT                   /note="Hemoglobin-haptoglobin utilization protein B"
FT                   /id="PRO_0000034761"
FT   MOTIF           793..810
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   810 AA;  90627 MW;  0D08DD79DA9CB817 CRC64;
     MPIPFKPVLA VAAIAQAFPA FAADPAPQSA QTLNEITVTG THKTQKLGEE KIRRKTLDKL
     LVNDEHDLVR YDPGISVVEG GRAGSNGFTI RGVDKDRVAI NVDGLAQAES RSSEAFQELF
     GAYGNFNANR NTSEPENFSE VTITKGADSL KSGSGALGGA VNYQTKSASD YVSEDKPYHL
     GIKGGSVGKN SQKFSSITAA GRLFGLDALL VYTRRFGKET KNRSTEGNVE IKNDGYVYNP
     TDTGGPSKYL TYVATGVARS QPDPQEWVNK STLFKLGYNF NDQNRIGWIF EDSRTDRFTN
     ELSNLWTGTT TSAATGDYRH RQDVSYRRRS GVEYKNELEH GPWDSLKLRY DKQRIDMNTW
     TWDIPKNYDL RGINSEVYHS FRHIRQNTAQ WTADFEKQLD FSKAVWAAQY GLGGGRGDNA
     NSDYSYFVKL YDPKILTSNQ AKITMLIENR SKYKFAYWNN VFHLGGNDRF RLNAGIRYDK
     NSSSAKDDPK YTTAIRGQIP HLGSERAHAG FSYGTGFDWR FTKHLHLLAK YSTGFRAPTS
     DETWLLFPHP DFYLKANPNL KAEKAKNWEL GLAGSGKAGN FKLSGFKTKY RDFIELTYMG
     VSSDNPNKPT YAPLSDGTAL VSSPVWQNQN RSSAWVKGLE FNGTWNLDSI GLPQGTHAGV
     NVSYIKGKAK QTNGQETPIN ALSPWSAVYN LGYDAPSKRW GINAYATRTA AKKPSDTVHS
     NDDLNNPWPY AKHSKAYTLF DLSAYLNIGK QVTLRAAAYN ITNKQYYTWE SLRSIREFGT
     VNRVDNKTHA GIQRFTSPGR SYNFTIEAKF