HR1_ARATH
ID HR1_ARATH Reviewed; 189 AA.
AC Q9SCS9; Q9C5Z4;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=RPW8-like protein 1 {ECO:0000303|PubMed:11141561};
DE Short=AtHR1 {ECO:0000303|PubMed:15155802};
GN Name=HR1 {ECO:0000303|PubMed:11141561}; Synonyms=HR1KZ10;
GN OrderedLocusNames=At3g50450 {ECO:0000312|Araport:AT3G50450};
GN ORFNames=T20E23.50 {ECO:0000312|EMBL:CAB62474.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Ms-0;
RX PubMed=11141561; DOI=10.1126/science.291.5501.118;
RA Xiao S., Ellwood S., Calis O., Patrick E., Li T., Coleman M., Turner J.G.;
RT "Broad-spectrum mildew resistance in Arabidopsis thaliana mediated by
RT RPW8.";
RL Science 291:118-120(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP INDUCTION BY ERYSIPHE CICHORACEARUM, AND GENE FAMILY.
RX PubMed=15155802; DOI=10.1093/molbev/msh165;
RA Xiao S., Emerson B., Ratanasut K., Patrick E., O'Neill C., Bancroft I.,
RA Turner J.G.;
RT "Origin and maintenance of a broad-spectrum disease resistance locus in
RT Arabidopsis.";
RL Mol. Biol. Evol. 21:1661-1672(2004).
CC -!- FUNCTION: Probable disease resistance (R) protein. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Expressed in leaves after powdery mildew infection (e.g.
CC Erysiphe cichoracearum UCSC1). {ECO:0000269|PubMed:15155802}.
CC -!- SIMILARITY: Belongs to the plant RPW8 protein family. {ECO:0000305}.
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DR EMBL; AF273059; AAK09270.1; -; Genomic_DNA.
DR EMBL; AL133363; CAB62474.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78668.1; -; Genomic_DNA.
DR PIR; T46076; T46076.
DR RefSeq; NP_190614.1; NM_114905.2.
DR AlphaFoldDB; Q9SCS9; -.
DR SMR; Q9SCS9; -.
DR STRING; 3702.AT3G50450.1; -.
DR PaxDb; Q9SCS9; -.
DR PRIDE; Q9SCS9; -.
DR EnsemblPlants; AT3G50450.1; AT3G50450.1; AT3G50450.
DR GeneID; 824209; -.
DR Gramene; AT3G50450.1; AT3G50450.1; AT3G50450.
DR KEGG; ath:AT3G50450; -.
DR Araport; AT3G50450; -.
DR TAIR; locus:2098700; AT3G50450.
DR eggNOG; ENOG502SXRU; Eukaryota.
DR HOGENOM; CLU_1436271_0_0_1; -.
DR InParanoid; Q9SCS9; -.
DR OMA; IDIHFRW; -.
DR OrthoDB; 1739242at2759; -.
DR PhylomeDB; Q9SCS9; -.
DR PRO; PR:Q9SCS9; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SCS9; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR GO; GO:0009620; P:response to fungus; IEP:UniProtKB.
DR InterPro; IPR008808; Powdery_mildew-R_dom.
DR InterPro; IPR039203; RPW8-like.
DR PANTHER; PTHR36766; PTHR36766; 1.
DR Pfam; PF05659; RPW8; 1.
DR PROSITE; PS51153; RPW8; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Glycoprotein; Hypersensitive response; Membrane;
KW Plant defense; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..189
FT /note="RPW8-like protein 1"
FT /id="PRO_0000431671"
FT TRANSMEM 7..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..153
FT /note="RPW8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00495"
FT COILED 65..92
FT /evidence="ECO:0000255"
FT COILED 126..147
FT /evidence="ECO:0000255"
FT CARBOHYD 177
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CONFLICT 21
FT /note="D -> E (in Ref. 1; AAK09270)"
FT /evidence="ECO:0000305"
FT CONFLICT 29..30
FT /note="RS -> KT (in Ref. 1; AAK09270)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 189 AA; 22344 MW; 5460C38D01BB2FAB CRC64;
MPLVELLTSA ALGLSLQLLH DAIIRAKERS LITRCILDRL DATLHKITPF VIKIDTLTEE
VDEPFRKVIE ELKRLLEKAI RLVDAYAELK LRNLLRKYRY KRRIKELDSS LRWMIDVDVQ
VNQWLDIKKL MGKMSEMNTK LDDITRQPMD IIEATGRSSE EDGCTKPTID IHFRWKNQTK
EHEIRFIFK
