HR2_ARATH
ID HR2_ARATH Reviewed; 205 AA.
AC Q9SCS8; A0A068LL46; Q9C5Z5;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=RPW8-like protein 2 {ECO:0000303|PubMed:11141561};
DE Short=AtHR2 {ECO:0000303|PubMed:15155802};
GN Name=HR2 {ECO:0000303|PubMed:11141561};
GN Synonyms=HR2KZ10 {ECO:0000303|Ref.2};
GN OrderedLocusNames=At3g50460 {ECO:0000312|Araport:AT3G50460};
GN ORFNames=T20E23.60 {ECO:0000312|EMBL:CAB62475.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Ms-0;
RX PubMed=11141561; DOI=10.1126/science.291.5501.118;
RA Xiao S., Ellwood S., Calis O., Patrick E., Li T., Coleman M., Turner J.G.;
RT "Broad-spectrum mildew resistance in Arabidopsis thaliana mediated by
RT RPW8.";
RL Science 291:118-120(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Chae E., Bomblies K., Kim S.-T., Karelina D., Zaidem M., Ossowski S.,
RA Martin Pizarro C., Laitinen R.A., Rowan B.A., Tenenboim H., Lechner S.,
RA Demar M., Habring-Mueller A., Lanz C., Raetsch G., Weigel D.;
RT "A species-wide analysis of genetic incompatibilities identifies NLR loci
RT as hotspots of deleterious epistasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP INDUCTION BY ERYSIPHE CICHORACEARUM, AND GENE FAMILY.
RX PubMed=15155802; DOI=10.1093/molbev/msh165;
RA Xiao S., Emerson B., Ratanasut K., Patrick E., O'Neill C., Bancroft I.,
RA Turner J.G.;
RT "Origin and maintenance of a broad-spectrum disease resistance locus in
RT Arabidopsis.";
RL Mol. Biol. Evol. 21:1661-1672(2004).
CC -!- FUNCTION: Probable disease resistance (R) protein. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Expressed in leaves after powdery mildew infection (e.g.
CC Erysiphe cichoracearum UCSC1). {ECO:0000269|PubMed:15155802}.
CC -!- SIMILARITY: Belongs to the plant RPW8 protein family. {ECO:0000305}.
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DR EMBL; AF273059; AAK09269.1; -; Genomic_DNA.
DR EMBL; KJ634211; AIE47873.1; -; Genomic_DNA.
DR EMBL; AL133363; CAB62475.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78669.1; -; Genomic_DNA.
DR PIR; T46077; T46077.
DR RefSeq; NP_190615.1; NM_114906.2.
DR AlphaFoldDB; Q9SCS8; -.
DR SMR; Q9SCS8; -.
DR STRING; 3702.AT3G50460.1; -.
DR PaxDb; Q9SCS8; -.
DR PRIDE; Q9SCS8; -.
DR EnsemblPlants; AT3G50460.1; AT3G50460.1; AT3G50460.
DR GeneID; 824210; -.
DR Gramene; AT3G50460.1; AT3G50460.1; AT3G50460.
DR KEGG; ath:AT3G50460; -.
DR Araport; AT3G50460; -.
DR TAIR; locus:2098715; AT3G50460.
DR HOGENOM; CLU_1436271_0_0_1; -.
DR InParanoid; Q9SCS8; -.
DR OMA; NQWADIK; -.
DR OrthoDB; 1446141at2759; -.
DR PhylomeDB; Q9SCS8; -.
DR PRO; PR:Q9SCS8; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SCS8; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR GO; GO:0009620; P:response to fungus; IEP:UniProtKB.
DR InterPro; IPR008808; Powdery_mildew-R_dom.
DR InterPro; IPR039203; RPW8-like.
DR PANTHER; PTHR36766; PTHR36766; 1.
DR Pfam; PF05659; RPW8; 1.
DR PROSITE; PS51153; RPW8; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Hypersensitive response; Membrane; Plant defense;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..205
FT /note="RPW8-like protein 2"
FT /id="PRO_0000431672"
FT TRANSMEM 7..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..153
FT /note="RPW8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00495"
FT COILED 70..92
FT /evidence="ECO:0000255"
FT COILED 125..147
FT /evidence="ECO:0000255"
FT CONFLICT 96
FT /note="G -> E (in Ref. 1; AAK09269)"
FT /evidence="ECO:0000305"
FT CONFLICT 159
FT /note="N -> K (in Ref. 2; AIE47873)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 205 AA; 23441 MW; 7AB098AAB84E37E3 CRC64;
MPLTEIIAGA ALGLALQILH EAIQRAKDRS LTTSCILDRL DSTILRITPL MAKVEKLNKE
SDESLRKVFE DLKHLLEKAV VLVEAYAELK RRNLLGKYRY KRRIKELEGS LKWMVDVDVK
VNQWADIKDL MAKMSEMNTK LEKIMGQPID CIISEDNTNM DIVERVDPSL EAKAGCSNSD
SKPKIDIHLR WSKQSKDHGI RFVLN
