HR38_BOMMO
ID HR38_BOMMO Reviewed; 360 AA.
AC P49870;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Probable nuclear hormone receptor HR38;
DE Short=bHR38;
DE AltName: Full=Nuclear receptor subfamily 4 group A member 4;
DE Flags: Fragment;
GN Name=HR38; Synonyms=NR4A4;
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Ovary;
RX PubMed=7644522; DOI=10.1073/pnas.92.17.7966;
RA Sutherland J.D., Kozlova T., Tzertzinis G., Kafatos F.C.;
RT "Drosophila hormone receptor 38: a second partner for Drosophila USP
RT suggests an unexpected role for nuclear receptors of the nerve growth
RT factor-induced protein B type.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:7966-7970(1995).
CC -!- SUBUNIT: Forms a heterodimer with USP.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR4
CC subfamily. {ECO:0000305}.
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DR EMBL; X89247; CAA61535.1; -; mRNA.
DR PIR; S58205; S58205.
DR AlphaFoldDB; P49870; -.
DR SMR; P49870; -.
DR DIP; DIP-927N; -.
DR STRING; 7091.BGIBMGA002964-TA; -.
DR eggNOG; KOG4217; Eukaryota.
DR HOGENOM; CLU_007368_14_1_1; -.
DR InParanoid; P49870; -.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR003070; Nuc_orph_rcpt.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01284; NUCLEARECPTR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN <1..360
FT /note="Probable nuclear hormone receptor HR38"
FT /id="PRO_0000053726"
FT DOMAIN 122..357
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 23..98
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 26..46
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 62..86
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
SQ SEQUENCE 360 AA; 39685 MW; 5E83554BC17C6C27 CRC64;
GSSSPGVAPA DNTGPRAAPS SPSQLCAVCG DTAACQHYGV RTCEGCKGFF KRTVQKGSKY
VCLAEKSCPV DKRRRNRCQF CWFQKCLAVG MVKEVVRTDS LKGRRGRLPS KPKCPQESPP
SPPISLITAL VRAHVDTSPD FANLDYSQYR EPSPLEPPMS DLEVIQQFYS LLTTSIDMIK
LFAEKVPGYG DLCPEDREQL FASARLELFV LRLAYRTALE DTKLTFSNGS VLDKRQCQRS
FGDWLHAVLD FSNTSYSMDI DISTFACLCA LTLITDRHGL KEPHRVEQVQ MKIIGCLRGH
MPGGGGSSSG AAPLQRVLGA LPELRSLSVK ASQRIFYLKL EDLVPAPPLI ENMFRASLPF
