HR3_ARATH
ID HR3_ARATH Reviewed; 213 AA.
AC Q9SCS7; A0A068LKP2;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=RPW8-like protein 3 {ECO:0000303|PubMed:11141561};
DE Short=AtHR3 {ECO:0000303|PubMed:15155802};
GN Name=HR3 {ECO:0000303|PubMed:11141561};
GN Synonyms=HR3KZ10 {ECO:0000303|Ref.2};
GN OrderedLocusNames=At3g50470 {ECO:0000312|Araport:AT3G50470};
GN ORFNames=T20E23.70 {ECO:0000312|EMBL:CAB62476.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Ms-0;
RX PubMed=11141561; DOI=10.1126/science.291.5501.118;
RA Xiao S., Ellwood S., Calis O., Patrick E., Li T., Coleman M., Turner J.G.;
RT "Broad-spectrum mildew resistance in Arabidopsis thaliana mediated by
RT RPW8.";
RL Science 291:118-120(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Chae E., Bomblies K., Kim S.-T., Karelina D., Zaidem M., Ossowski S.,
RA Martin Pizarro C., Laitinen R.A., Rowan B.A., Tenenboim H., Lechner S.,
RA Demar M., Habring-Mueller A., Lanz C., Raetsch G., Weigel D.;
RT "A species-wide analysis of genetic incompatibilities identifies NLR loci
RT as hotspots of deleterious epistasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP INDUCTION BY ERYSIPHE CICHORACEARUM, AND GENE FAMILY.
RX PubMed=15155802; DOI=10.1093/molbev/msh165;
RA Xiao S., Emerson B., Ratanasut K., Patrick E., O'Neill C., Bancroft I.,
RA Turner J.G.;
RT "Origin and maintenance of a broad-spectrum disease resistance locus in
RT Arabidopsis.";
RL Mol. Biol. Evol. 21:1661-1672(2004).
CC -!- FUNCTION: Probable disease resistance (R) protein. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Expressed in leaves after powdery mildew infection (e.g.
CC Erysiphe cichoracearum UCSC1). {ECO:0000269|PubMed:15155802}.
CC -!- SIMILARITY: Belongs to the plant RPW8 protein family. {ECO:0000305}.
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DR EMBL; AF273059; AAK09268.1; -; Genomic_DNA.
DR EMBL; KJ634211; AIE47874.1; -; Genomic_DNA.
DR EMBL; AL133363; CAB62476.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78670.1; -; Genomic_DNA.
DR EMBL; AK175750; BAD43513.1; -; mRNA.
DR PIR; T46078; T46078.
DR RefSeq; NP_190616.1; NM_114907.3.
DR AlphaFoldDB; Q9SCS7; -.
DR SMR; Q9SCS7; -.
DR STRING; 3702.AT3G50470.1; -.
DR PaxDb; Q9SCS7; -.
DR PRIDE; Q9SCS7; -.
DR ProteomicsDB; 228746; -.
DR EnsemblPlants; AT3G50470.1; AT3G50470.1; AT3G50470.
DR GeneID; 824211; -.
DR Gramene; AT3G50470.1; AT3G50470.1; AT3G50470.
DR KEGG; ath:AT3G50470; -.
DR Araport; AT3G50470; -.
DR TAIR; locus:2098725; AT3G50470.
DR eggNOG; ENOG502SXRU; Eukaryota.
DR HOGENOM; CLU_1436271_0_0_1; -.
DR InParanoid; Q9SCS7; -.
DR OMA; DEITRQP; -.
DR OrthoDB; 1332879at2759; -.
DR PhylomeDB; Q9SCS7; -.
DR PRO; PR:Q9SCS7; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SCS7; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR GO; GO:0009620; P:response to fungus; IEP:UniProtKB.
DR InterPro; IPR008808; Powdery_mildew-R_dom.
DR InterPro; IPR039203; RPW8-like.
DR PANTHER; PTHR36766; PTHR36766; 1.
DR Pfam; PF05659; RPW8; 1.
DR PROSITE; PS51153; RPW8; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Glycoprotein; Hypersensitive response; Membrane;
KW Plant defense; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..213
FT /note="RPW8-like protein 3"
FT /id="PRO_0000431673"
FT TRANSMEM 7..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..153
FT /note="RPW8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00495"
FT COILED 70..93
FT /evidence="ECO:0000255"
FT COILED 125..147
FT /evidence="ECO:0000255"
FT CARBOHYD 157
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CONFLICT 81
FT /note="S -> C (in Ref. 2; AIE47874)"
FT /evidence="ECO:0000305"
FT CONFLICT 157
FT /note="N -> K (in Ref. 2; AIE47874)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 213 AA; 24690 MW; E1AFB6B9E0243A77 CRC64;
MPVSEIMAGA ALGLALQVLH DAIKKAKDRS LTTRCILDRL DATIFRITPL VTQVDKLSEE
VEDSPRKVIE DLKHLLEKAV SLVEAYAELR RRNLLKKFRY KRRIKELEAS LRWMVDVDVQ
VNQWVDIKEL MAKMSEMNTK LDEITRQPTD CICFKSNHST SQSSSQNIVE ETDRSLEEIV
ECSSDGSKPK IDIHIHWSSR KRNKDREIRF VLK
