HR3_DROME
ID HR3_DROME Reviewed; 487 AA.
AC P31396; Q9V5I0;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 192.
DE RecName: Full=Probable nuclear hormone receptor HR3 {ECO:0000303|PubMed:1631105};
DE Short=dHR3 {ECO:0000303|PubMed:1631105};
DE AltName: Full=Nuclear receptor subfamily 1 group F member 4 {ECO:0000305};
GN Name=Hr3 {ECO:0000303|PubMed:1631105, ECO:0000312|FlyBase:FBgn0000448};
GN Synonyms=Hr46 {ECO:0000312|FlyBase:FBgn0000448};
GN ORFNames=CG11823 {ECO:0000312|FlyBase:FBgn0000448};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1631105; DOI=10.1073/pnas.89.13.6167;
RA Koelle M.R., Segraves W.A., Hogness D.S.;
RT "DHR3: a Drosophila steroid receptor homolog.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:6167-6171(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Putative receptor whose ligand is not yet known.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- INDUCTION: The expression of this protein is developmentally regulated
CC showing peaks at midembryogenesis. HR3 transcription is ecdysone-
CC induced.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M90806; AAA28461.1; -; mRNA.
DR EMBL; AE013599; AAF58826.1; -; Genomic_DNA.
DR PIR; A46146; A46146.
DR RefSeq; NP_001246236.1; NM_001259307.3.
DR RefSeq; NP_788303.1; NM_176123.5.
DR AlphaFoldDB; P31396; -.
DR SMR; P31396; -.
DR BioGRID; 61895; 19.
DR IntAct; P31396; 5.
DR STRING; 7227.FBpp0291630; -.
DR ChEMBL; CHEMBL2321624; -.
DR PaxDb; P31396; -.
DR EnsemblMetazoa; FBtr0088368; FBpp0087456; FBgn0000448.
DR EnsemblMetazoa; FBtr0306345; FBpp0297438; FBgn0000448.
DR GeneID; 36073; -.
DR KEGG; dme:Dmel_CG33183; -.
DR CTD; 36073; -.
DR FlyBase; FBgn0000448; Hr3.
DR VEuPathDB; VectorBase:FBgn0000448; -.
DR eggNOG; KOG4216; Eukaryota.
DR HOGENOM; CLU_007368_2_1_1; -.
DR InParanoid; P31396; -.
DR PhylomeDB; P31396; -.
DR Reactome; R-DME-383280; Nuclear Receptor transcription pathway.
DR Reactome; R-DME-4090294; SUMOylation of intracellular receptors.
DR SignaLink; P31396; -.
DR BioGRID-ORCS; 36073; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Hr46; fly.
DR GenomeRNAi; 36073; -.
DR PRO; PR:P31396; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0000448; Expressed in saliva-secreting gland and 29 other tissues.
DR ExpressionAtlas; P31396; baseline and differential.
DR Genevisible; P31396; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0004879; F:nuclear receptor activity; IDA:FlyBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007552; P:metamorphosis; TAS:FlyBase.
DR GO; GO:0016319; P:mushroom body development; IMP:FlyBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0040034; P:regulation of development, heterochronic; TAS:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd06968; NR_DBD_ROR; 1.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR044101; NR_DBD_ROR.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001728; ThyrH_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00546; THYROIDHORMR.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..487
FT /note="Probable nuclear hormone receptor HR3"
FT /id="PRO_0000053519"
FT DOMAIN 237..480
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 48..123
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 51..71
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 87..111
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 145..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 487 AA; 55285 MW; 774587D2E79204EC CRC64;
MYTQRMFDMW SSVTSKLEAH ANNLGQSNVQ SPAGQNNSSG SIKAQIEIIP CKVCGDKSSG
VHYGVITCEG CKGFFRRSQS SVVNYQCPRN KQCVVDRVNR NRCQYCRLQK CLKLGMSRDA
VKFGRMSKKQ REKVEDEVRF HRAQMRAQSD AAPDSSVYDT QTPSSSDQLH HNNYNSYSGG
YSNNEVGYGS PYGYSASVTP QQTMQYDISA DYVDSTTYEP RSTIIDPEFI SHADGDINDV
LIKTLAEAHA NTNTKLEAVH DMFRKQPDVS RILYYKNLGQ EELWLDCAEK LTQMIQNIIE
FAKLIPGFMR LSQDDQILLL KTGSFELAIV RMSRLLDLSQ NAVLYGDVML PQEAFYTSDS
EEMRLVSRIF QTAKSIAELK LTETELALYQ SLVLLWPERN GVRGNTEIQR LFNLSMNAIR
QELETNHAPL KGDVTVLDTL LNNIPNFRDI SILHMESLSK FKLQHPNVVF PALYKELFSI
DSQQDLT
