ID   HR3_GALME               Reviewed;         557 AA.
AC   P49868;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Probable nuclear hormone receptor HR3;
DE            Short=gHR3;
DE   AltName: Full=Nuclear receptor subfamily 1 group F member 4;
GN   Name=HR3; Synonyms=NR1F4;
OS   Galleria mellonella (Greater wax moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Pyraloidea;
OC   Pyralidae; Galleriinae; Galleria.
OX   NCBI_TaxID=7137;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7981726; DOI=10.1016/0965-1748(94)90105-8;
RA   Jindra M., Sehnal F., Riddiford L.M.;
RT   "Isolation and developmental expression of the ecdysteroid-induced GHR3
RT   gene of the wax moth Galleria mellonella.";
RL   Insect Biochem. Mol. Biol. 24:763-773(1994).
CC   -!- FUNCTION: Putative receptor whose ligand is not yet known.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- INDUCTION: By ecdysteroid.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; U02621; AAA83401.1; -; mRNA.
DR   AlphaFoldDB; P49868; -.
DR   SMR; P49868; -.
DR   Proteomes; UP000504614; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd06968; NR_DBD_ROR; 1.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR044101; NR_DBD_ROR.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001728; ThyrH_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00546; THYROIDHORMR.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..557
FT                   /note="Probable nuclear hormone receptor HR3"
FT                   /id="PRO_0000053520"
FT   DOMAIN          304..548
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        105..180
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         108..128
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         144..168
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..229
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   557 AA;  62316 MW;  DA518DB12B978589 CRC64;
     MNNSQFHELF GSQWPPDQHG GHSSASTMLH QAQSPLPQGM RLKREPHTDV QGVMHNQMGM
     DITSGSVADS TSPPPGSSEG MFGSSISGMF MDKKAANSIR AQIEIIPCKV CGDKSSGVHY
     GVITCEGCKG FFRRSQSTVV NYQCPRNKAC VVDRVNRNRC QYCRLQKCLK LGMSRDAVKF
     GRMSKKQREK VEDEVRYHRA QMRAQTDAAP DSVYDAQQQT PSSSDQFHGH YNGYPGYRSP
     LSSYGYGGNA GPALTSNMNI QPQAPQQQPY DVSADYVDST TAYEPKQTGG FLDADFIGHA
     EGDISKVLVK SLAEAHANTN PKLEYVHEMF RKPPDVSKLL FYNSMTYEEM WLDCADKLTG
     MIQNIIEFAK LIPGFMKLSQ DDQILLLKSG SFELAIVRLS RLIDVNREQV LYGDVVLPIR
     ECVHARDPRD VTLVVGIFDA AKTIERLKLT ETELALYQSL VLLWPERHGV RGNPEIQCLF
     NMSMAAMRHE IESNHAPLKG DVTVLDTLLA KIPTFRELSL MHLEALCRFK AAHPHHVFPA
     LYKELFSLDS VLDYTHG