HR3_MANSE
ID HR3_MANSE Reviewed; 548 AA.
AC Q08882;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Probable nuclear hormone receptor HR3;
DE Short=mHR3;
DE AltName: Full=Nuclear receptor subfamily 1 group F member 4;
GN Name=HR3; Synonyms=NR1F4;
OS Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Sphingidae; Sphinginae; Sphingini; Manduca.
OX NCBI_TaxID=7130;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1372571; DOI=10.1016/0012-1606(92)90244-b;
RA Palli S.R., Hiruma K., Riddiford L.M.;
RT "An ecdysteroid-inducible Manduca gene similar to the Drosophila DHR3 gene,
RT a member of the steroid hormone receptor superfamily.";
RL Dev. Biol. 150:306-318(1992).
CC -!- FUNCTION: Putative receptor whose ligand is not yet known.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily. {ECO:0000305}.
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DR EMBL; X74566; CAA52654.1; -; mRNA.
DR AlphaFoldDB; Q08882; -.
DR SMR; Q08882; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06968; NR_DBD_ROR; 1.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR044101; NR_DBD_ROR.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001728; ThyrH_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00546; THYROIDHORMR.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..548
FT /note="Probable nuclear hormone receptor HR3"
FT /id="PRO_0000053521"
FT DOMAIN 295..539
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 101..176
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 104..124
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 140..164
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 548 AA; 61588 MW; 781475BF9BC21E17 CRC64;
MNNNQFHELF GSQWPPDQHG GHSSASTMLH QQTMPQTMQL KREPHTEVGV MHNQMGMDIT
SGSVADSTSP PPGSSEGMFG PISGMFMDKK AANSIRAQIE IIPCKVCGDK SSGVHYGVIT
CEGCKGFFRR SQSTVVNYQC PRNKACVVDR VNRNRCQYCR LQKCLKLGMS RDAVKFGRMS
KKQREKVEDE VRYHKAQMRA QNDAAPDSVY DAQQQTPSSS DQFHGHYNGY PGYASPLSSY
GYNNAGPPLT SNMSSIQAQP QAQQPYDYAD STTTYEPKQP GYLDADFIGQ VEGDISKVLV
KSLAERHANT NPKLEYINEM FSKPQDVSKL LFYNSMTYEE MWLDCADKLT AMIQNIIEFA
KLIPGFMKLT QDDQILLLKS GSFELAIVRL SRLIDVNREQ VLYGDVVLPI RECVHARDPR
DMALVSGIFE AAKSIARLKL TESELALYQS LVLLWPERHG VMGNTEIRCL FNMSMSAMRH
EIEANHAPLK GDVTVLDTLL AKIPTFRELS LMHLGALSRF KMTHPHHVFP ALYKELFSLD
SVLDYTHG
