HR96_DROME
ID HR96_DROME Reviewed; 723 AA.
AC Q24143; Q9VBZ7;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 185.
DE RecName: Full=Nuclear hormone receptor HR96;
DE Short=dHR96;
DE AltName: Full=Nuclear receptor subfamily 1 group J member 1;
GN Name=Hr96; Synonyms=NR1J1; ORFNames=CG11783;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RX PubMed=7479849; DOI=10.1073/pnas.92.23.10604;
RA Fisk G.J., Thummel C.S.;
RT "Isolation, regulation, and DNA-binding properties of three Drosophila
RT nuclear hormone receptor superfamily members.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:10604-10608(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Binds selectively to the HSP27 20E response element.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Highest expression in third-instar larvae and
CC prepupae.
CC -!- INDUCTION: By 20-hydroxyecdysone (20HE) 106 hours after egg laying.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily. {ECO:0000305}.
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DR EMBL; U36792; AAC46928.1; -; mRNA.
DR EMBL; AE014297; AAF56379.1; -; Genomic_DNA.
DR EMBL; AY051486; AAK92910.1; -; mRNA.
DR RefSeq; NP_524493.1; NM_079769.3.
DR AlphaFoldDB; Q24143; -.
DR SMR; Q24143; -.
DR BioGRID; 67914; 5.
DR DIP; DIP-20167N; -.
DR IntAct; Q24143; 3.
DR STRING; 7227.FBpp0084131; -.
DR PaxDb; Q24143; -.
DR PRIDE; Q24143; -.
DR EnsemblMetazoa; FBtr0084756; FBpp0084131; FBgn0015240.
DR GeneID; 42993; -.
DR KEGG; dme:Dmel_CG11783; -.
DR CTD; 42993; -.
DR FlyBase; FBgn0015240; Hr96.
DR VEuPathDB; VectorBase:FBgn0015240; -.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00940000171624; -.
DR HOGENOM; CLU_007368_12_2_1; -.
DR InParanoid; Q24143; -.
DR OMA; IMNSPFN; -.
DR OrthoDB; 297114at2759; -.
DR PhylomeDB; Q24143; -.
DR Reactome; R-DME-159418; Recycling of bile acids and salts.
DR Reactome; R-DME-196791; Vitamin D (calciferol) metabolism.
DR Reactome; R-DME-383280; Nuclear Receptor transcription pathway.
DR Reactome; R-DME-4090294; SUMOylation of intracellular receptors.
DR Reactome; R-DME-9029569; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux.
DR Reactome; R-DME-9623433; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis.
DR SignaLink; Q24143; -.
DR BioGRID-ORCS; 42993; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 42993; -.
DR PRO; PR:Q24143; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0015240; Expressed in embryonic/larval hemocyte (Drosophila) and 25 other tissues.
DR Genevisible; Q24143; DM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0042632; P:cholesterol homeostasis; IMP:FlyBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0070873; P:regulation of glycogen metabolic process; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0042594; P:response to starvation; IMP:FlyBase.
DR GO; GO:0070328; P:triglyceride homeostasis; IMP:FlyBase.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..723
FT /note="Nuclear hormone receptor HR96"
FT /id="PRO_0000053557"
FT DOMAIN 483..723
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 4..79
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 7..27
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 43..67
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 95..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 723 AA; 81029 MW; 439CC96A723AE9B6 CRC64;
MSPPKNCAVC GDKALGYNFN AVTCESCKAF FRRNALAKKQ FTCPFNQNCD ITVVTRRFCQ
KCRLRKCLDI GMKSENIMSE EDKLIKRRKI ETNRAKRRLM ENGTDACDAD GGEERDHKAP
ADSSSSNLDH YSGSQDSQSC GSADSGANGC SGRQASSPGT QVNPLQMTAE KIVDQIVSDP
DRASQAINRL MRTQKEAISV MEKVISSQKD ALRLVSHLID YPGDALKIIS KFMNSPFNAL
TVFTKFMSSP TDGVEIISKI VDSPADVVEF MQNLMHSPED AIDIMNKFMN TPAEALRILN
RILSGGGANA AQQTADRKPL LDKEPAVKPA APAERADTVI QSMLGNSPPI SPHDAAVDLQ
YHSPGVGEQP STSSSHPLPY IANSPDFDLK TFMQTNYNDE PSLDSDFSIN SIESVLSEVI
RIEYQAFNSI QQAASRVKEE MSYGTQSTYG GCNSAANNSQ PHLQQPICAP STQQLDRELN
EAEQMKLREL RLASEALYDP VDEDLSALMM GDDRIKPDDT RHNPKLLQLI NLTAVAIKRL
IKMAKKITAF RDMCQEDQVA LLKGGCTEMM IMRSVMIYDD DRAAWKVPHT KENMGNIRTD
LLKFAEGNIY EEHQKFITTF DEKWRMDENI ILIMCAIVLF TSARSRVIHK DVIRLEQNSY
YYLLRRYLES VYSGCEARNA FIKLIQKISD VERLNKFIIN VYLNVNPSQV EPLLREIFDL
KNH
